Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats

Cisplatin (CP) is the most effective chemotherapeutic drug used to treat various types of solid tumors. Morin is a natural flavonoid having a wide range of pharmacological properties. This investigation was aimed to explore the curative effect of morin against CP persuaded mitochondrial dysfunction...

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Autores principales:	Muhammad Umar Ijaz, Sabahat Shahzadi, Zartash Zahra, Abdul Samad, Nazia Ehsan, Tayyaba Afsar, Ali Almajwal, Dara Al-disi, Mahmoud Abulmeaty, Suhail Razak
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cisplatin Mitochondrial injuries Morin Natural flavonoid Antioxidant Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/53058fbd440a4e86b96a3181415d61b7
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spelling	oai:doaj.org-article:53058fbd440a4e86b96a3181415d61b72021-11-18T04:44:26ZAmeliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats1018-364710.1016/j.jksus.2021.101655https://doaj.org/article/53058fbd440a4e86b96a3181415d61b72021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003177https://doaj.org/toc/1018-3647Cisplatin (CP) is the most effective chemotherapeutic drug used to treat various types of solid tumors. Morin is a natural flavonoid having a wide range of pharmacological properties. This investigation was aimed to explore the curative effect of morin against CP persuaded mitochondrial dysfunction in renal tissues of rats. Adult male Sprague-Dawley rats (n = 24) were randomly distributed into four groups for this experiment; control group, CP administered group, CP + morin administered group, and morin administered group. The results showed adverse effects of CP on renal biomarkers by elevating and reducing the level of urea, creatinine, and creatinine clearance sequentially. The antioxidant enzymatic and non-enzymatic activities, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH) levels were significantly decreased in renal mitochondria of CP-exposed rats. CP administration significantly elevated the ROS and TBARS levels. CP administration remarkably reduced TCA cycle enzymes activity, including succinate dehydrogenase (SDH), malate dehydrogenase (MDH), isocitrate dehydrogenase (ICDH) and alpha-ketoglutarate dehydrogenase (α-KGDH). Moreover, mitochondrial electron transport chain (ETC) enzymes, such as succinic-coenzyme Q, NADH dehydrogenase, Cytochrome c-oxidase, and coenzyme Q-cytochrome reductase activities, were also reduced after CP treatment. CP-induction significantly reduced the mitochondria membrane potential (ΔΨm). Nonetheless, morin supplementation significantly ameliorated the damaging impacts of CP in isolated mitochondria from renal tissues of rats. Thus, the present study revealed that the morin has conspicuous potential to attenuate the CP-instigated mitochondrial injuries in the renal tissues of adult male Sprague-Dawley rats.Muhammad Umar IjazSabahat ShahzadiZartash ZahraAbdul SamadNazia EhsanTayyaba AfsarAli AlmajwalDara Al-disiMahmoud AbulmeatySuhail RazakElsevierarticleCisplatinMitochondrial injuriesMorinNatural flavonoidAntioxidantScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101655- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cisplatin Mitochondrial injuries Morin Natural flavonoid Antioxidant Science (General) Q1-390
spellingShingle	Cisplatin Mitochondrial injuries Morin Natural flavonoid Antioxidant Science (General) Q1-390 Muhammad Umar Ijaz Sabahat Shahzadi Zartash Zahra Abdul Samad Nazia Ehsan Tayyaba Afsar Ali Almajwal Dara Al-disi Mahmoud Abulmeaty Suhail Razak Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
description	Cisplatin (CP) is the most effective chemotherapeutic drug used to treat various types of solid tumors. Morin is a natural flavonoid having a wide range of pharmacological properties. This investigation was aimed to explore the curative effect of morin against CP persuaded mitochondrial dysfunction in renal tissues of rats. Adult male Sprague-Dawley rats (n = 24) were randomly distributed into four groups for this experiment; control group, CP administered group, CP + morin administered group, and morin administered group. The results showed adverse effects of CP on renal biomarkers by elevating and reducing the level of urea, creatinine, and creatinine clearance sequentially. The antioxidant enzymatic and non-enzymatic activities, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH) levels were significantly decreased in renal mitochondria of CP-exposed rats. CP administration significantly elevated the ROS and TBARS levels. CP administration remarkably reduced TCA cycle enzymes activity, including succinate dehydrogenase (SDH), malate dehydrogenase (MDH), isocitrate dehydrogenase (ICDH) and alpha-ketoglutarate dehydrogenase (α-KGDH). Moreover, mitochondrial electron transport chain (ETC) enzymes, such as succinic-coenzyme Q, NADH dehydrogenase, Cytochrome c-oxidase, and coenzyme Q-cytochrome reductase activities, were also reduced after CP treatment. CP-induction significantly reduced the mitochondria membrane potential (ΔΨm). Nonetheless, morin supplementation significantly ameliorated the damaging impacts of CP in isolated mitochondria from renal tissues of rats. Thus, the present study revealed that the morin has conspicuous potential to attenuate the CP-instigated mitochondrial injuries in the renal tissues of adult male Sprague-Dawley rats.
format	article
author	Muhammad Umar Ijaz Sabahat Shahzadi Zartash Zahra Abdul Samad Nazia Ehsan Tayyaba Afsar Ali Almajwal Dara Al-disi Mahmoud Abulmeaty Suhail Razak
author_facet	Muhammad Umar Ijaz Sabahat Shahzadi Zartash Zahra Abdul Samad Nazia Ehsan Tayyaba Afsar Ali Almajwal Dara Al-disi Mahmoud Abulmeaty Suhail Razak
author_sort	Muhammad Umar Ijaz
title	Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
title_short	Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
title_full	Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
title_fullStr	Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
title_full_unstemmed	Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
title_sort	ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/53058fbd440a4e86b96a3181415d61b7
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Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats

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