Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping

Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly establish chromatin loops.

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Detalles Bibliográficos
Autores principales:	Stefanie L. Morgan, Natasha C. Mariano, Abel Bermudez, Nicole L. Arruda, Fangting Wu, Yunhai Luo, Gautam Shankar, Lin Jia, Huiling Chen, Ji-Fan Hu, Andrew R. Hoffman, Chiao-Chain Huang, Sharon J. Pitteri, Kevin C. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5309d42ed5b04e42a18e02ba03f78364
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spelling	oai:doaj.org-article:5309d42ed5b04e42a18e02ba03f783642021-12-02T14:42:42ZManipulation of nuclear architecture through CRISPR-mediated chromosomal looping10.1038/ncomms159932041-1723https://doaj.org/article/5309d42ed5b04e42a18e02ba03f783642017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15993https://doaj.org/toc/2041-1723Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly establish chromatin loops.Stefanie L. MorganNatasha C. MarianoAbel BermudezNicole L. ArrudaFangting WuYunhai LuoGautam ShankarLin JiaHuiling ChenJi-Fan HuAndrew R. HoffmanChiao-Chain HuangSharon J. PitteriKevin C. WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefanie L. Morgan Natasha C. Mariano Abel Bermudez Nicole L. Arruda Fangting Wu Yunhai Luo Gautam Shankar Lin Jia Huiling Chen Ji-Fan Hu Andrew R. Hoffman Chiao-Chain Huang Sharon J. Pitteri Kevin C. Wang Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
description	Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly establish chromatin loops.
format	article
author	Stefanie L. Morgan Natasha C. Mariano Abel Bermudez Nicole L. Arruda Fangting Wu Yunhai Luo Gautam Shankar Lin Jia Huiling Chen Ji-Fan Hu Andrew R. Hoffman Chiao-Chain Huang Sharon J. Pitteri Kevin C. Wang
author_facet	Stefanie L. Morgan Natasha C. Mariano Abel Bermudez Nicole L. Arruda Fangting Wu Yunhai Luo Gautam Shankar Lin Jia Huiling Chen Ji-Fan Hu Andrew R. Hoffman Chiao-Chain Huang Sharon J. Pitteri Kevin C. Wang
author_sort	Stefanie L. Morgan
title	Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
title_short	Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
title_full	Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
title_fullStr	Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
title_full_unstemmed	Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
title_sort	manipulation of nuclear architecture through crispr-mediated chromosomal looping
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5309d42ed5b04e42a18e02ba03f78364
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Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping

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