The physical relationship between infectivity and prion protein aggregates is strain-dependent.
Prions are unconventional infectious agents thought to be primarily composed of PrP(Sc), a multimeric misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). They cause fatal neurodegenerative diseases in both animals and humans. The disease phenotype is not uniform wi...
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Autores principales: | Philippe Tixador, Laëtitia Herzog, Fabienne Reine, Emilie Jaumain, Jérôme Chapuis, Annick Le Dur, Hubert Laude, Vincent Béringue |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
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Materias: | |
Acceso en línea: | https://doaj.org/article/530c85bcc5e94f2588c40a6bac14eedf |
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