Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder

Abstract Variable mood is an important feature of psychiatric disorders. However, its measurement and relationship to objective measureas of physiology and behaviour have rarely been studied. Smart-phones facilitate continuous personalized prospective monitoring of subjective experience and behaviou...

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Autores principales:	O. Carr, K. E. A. Saunders, A. Tsanas, A. C. Bilderbeck, N. Palmius, J. R. Geddes, R. Foster, G. M. Goodwin, M. De Vos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/530f18d36e3f4979b8e4b42f359e0364
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spelling	oai:doaj.org-article:530f18d36e3f4979b8e4b42f359e03642021-12-02T15:09:12ZVariability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder10.1038/s41598-018-19888-92045-2322https://doaj.org/article/530f18d36e3f4979b8e4b42f359e03642018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19888-9https://doaj.org/toc/2045-2322Abstract Variable mood is an important feature of psychiatric disorders. However, its measurement and relationship to objective measureas of physiology and behaviour have rarely been studied. Smart-phones facilitate continuous personalized prospective monitoring of subjective experience and behavioural and physiological signals can be measured through wearable devices. Such passive data streams allow novel estimates of diurnal variability. Phase and amplitude of diurnal rhythms were quantified using new techniques that fitted sinusoids to heart rate (HR) and acceleration signals. We investigated mood and diurnal variation for four days in 20 outpatients with bipolar disorder (BD), 14 with borderline personality disorder (BPD) and 20 healthy controls (HC) using a smart-phone app, portable electrocardiogram (ECG), and actigraphy. Variability in negative affect, positive affect, and irritability was elevated in patient groups compared with HC. The study demonstrated convincing associations between variability in subjective mood and objective variability in diurnal physiology. For BPD there was a pattern of positive correlations between mood variability and variation in activity, sleep and HR. The findings suggest BPD is linked more than currently believed with a disorder of diurnal rhythm; in both BPD and BD reducing the variability of sleep phase may be a way to reduce variability of subjective mood.O. CarrK. E. A. SaundersA. TsanasA. C. BilderbeckN. PalmiusJ. R. GeddesR. FosterG. M. GoodwinM. De VosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q O. Carr K. E. A. Saunders A. Tsanas A. C. Bilderbeck N. Palmius J. R. Geddes R. Foster G. M. Goodwin M. De Vos Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
description	Abstract Variable mood is an important feature of psychiatric disorders. However, its measurement and relationship to objective measureas of physiology and behaviour have rarely been studied. Smart-phones facilitate continuous personalized prospective monitoring of subjective experience and behavioural and physiological signals can be measured through wearable devices. Such passive data streams allow novel estimates of diurnal variability. Phase and amplitude of diurnal rhythms were quantified using new techniques that fitted sinusoids to heart rate (HR) and acceleration signals. We investigated mood and diurnal variation for four days in 20 outpatients with bipolar disorder (BD), 14 with borderline personality disorder (BPD) and 20 healthy controls (HC) using a smart-phone app, portable electrocardiogram (ECG), and actigraphy. Variability in negative affect, positive affect, and irritability was elevated in patient groups compared with HC. The study demonstrated convincing associations between variability in subjective mood and objective variability in diurnal physiology. For BPD there was a pattern of positive correlations between mood variability and variation in activity, sleep and HR. The findings suggest BPD is linked more than currently believed with a disorder of diurnal rhythm; in both BPD and BD reducing the variability of sleep phase may be a way to reduce variability of subjective mood.
format	article
author	O. Carr K. E. A. Saunders A. Tsanas A. C. Bilderbeck N. Palmius J. R. Geddes R. Foster G. M. Goodwin M. De Vos
author_facet	O. Carr K. E. A. Saunders A. Tsanas A. C. Bilderbeck N. Palmius J. R. Geddes R. Foster G. M. Goodwin M. De Vos
author_sort	O. Carr
title	Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
title_short	Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
title_full	Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
title_fullStr	Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
title_full_unstemmed	Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
title_sort	variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/530f18d36e3f4979b8e4b42f359e0364
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Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder

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