Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry

Background: It has been reported that maternal gestational environment may be programmed to have a significant impact on foetal and offspring health later in life. Studies have shown that children born to pre-eclamptic mothers are prone to obesity, hypertension, and diabetes in their adult life. How...

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Autores principales:	Benedicta Ngwenchi Nkeh-Chungag, Godwill Azeh Engwa, Charles Businge, Kaltrina Kutllovci-Hasani, Andre P. Kengne, Nandu Goswami
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pre-eclampsia (PE) cardiovascular risk factor vascular dysfunction African ancestry blood pressure Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5312118723974eddba8c03fe1df4ae45
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spelling	oai:doaj.org-article:5312118723974eddba8c03fe1df4ae452021-11-30T12:32:30ZAssessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry2297-055X10.3389/fcvm.2021.773841https://doaj.org/article/5312118723974eddba8c03fe1df4ae452021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.773841/fullhttps://doaj.org/toc/2297-055XBackground: It has been reported that maternal gestational environment may be programmed to have a significant impact on foetal and offspring health later in life. Studies have shown that children born to pre-eclamptic mothers are prone to obesity, hypertension, and diabetes in their adult life. However, such findings are yet to be established in an African population. This protocol is for a study aiming to investigate the relationship between pre-eclampsia (PE) and cardiovascular risk in children born to pre-eclamptic mothers in a South African population of African descents.Methods: A prospective case-control design will be employed to recruit pre-eclamptic and normotensive pregnant women and their offspring after birth. Pregnant women will be assessed for cardiovascular risk factors including PE, obesity, haemodynamics, lipids, glycaemic indices, oxidative stress, and vascular function at 30 weeks of gestation. The cardiovascular risk profile of their offspring will be assessed at birth and 6 weeks later. The difference in cardiovascular risk profile between children born to the pre-eclamptic and normotensive mothers will be compared and the correlation between maternal and offspring cardiovascular risks will be investigated.Discussion: This will be the first prospective study to assess the in-utero effect of cardiovascular risk in offspring born to pre-eclamptic women of African ancestry. It is expected that findings from this study will provide information on the cardiovascular effect of in-utero exposure to PE in a population of African ancestry. This knowledge will advise policy on the management of women with PE with a view of protecting cardiovascular health in offspring.Benedicta Ngwenchi Nkeh-ChungagGodwill Azeh EngwaCharles BusingeKaltrina Kutllovci-HasaniAndre P. KengneNandu GoswamiNandu GoswamiNandu GoswamiFrontiers Media S.A.articlepre-eclampsia (PE)cardiovascular risk factorvascular dysfunctionAfrican ancestryblood pressureDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pre-eclampsia (PE) cardiovascular risk factor vascular dysfunction African ancestry blood pressure Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	pre-eclampsia (PE) cardiovascular risk factor vascular dysfunction African ancestry blood pressure Diseases of the circulatory (Cardiovascular) system RC666-701 Benedicta Ngwenchi Nkeh-Chungag Godwill Azeh Engwa Charles Businge Kaltrina Kutllovci-Hasani Andre P. Kengne Nandu Goswami Nandu Goswami Nandu Goswami Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry
description	Background: It has been reported that maternal gestational environment may be programmed to have a significant impact on foetal and offspring health later in life. Studies have shown that children born to pre-eclamptic mothers are prone to obesity, hypertension, and diabetes in their adult life. However, such findings are yet to be established in an African population. This protocol is for a study aiming to investigate the relationship between pre-eclampsia (PE) and cardiovascular risk in children born to pre-eclamptic mothers in a South African population of African descents.Methods: A prospective case-control design will be employed to recruit pre-eclamptic and normotensive pregnant women and their offspring after birth. Pregnant women will be assessed for cardiovascular risk factors including PE, obesity, haemodynamics, lipids, glycaemic indices, oxidative stress, and vascular function at 30 weeks of gestation. The cardiovascular risk profile of their offspring will be assessed at birth and 6 weeks later. The difference in cardiovascular risk profile between children born to the pre-eclamptic and normotensive mothers will be compared and the correlation between maternal and offspring cardiovascular risks will be investigated.Discussion: This will be the first prospective study to assess the in-utero effect of cardiovascular risk in offspring born to pre-eclamptic women of African ancestry. It is expected that findings from this study will provide information on the cardiovascular effect of in-utero exposure to PE in a population of African ancestry. This knowledge will advise policy on the management of women with PE with a view of protecting cardiovascular health in offspring.
format	article
author	Benedicta Ngwenchi Nkeh-Chungag Godwill Azeh Engwa Charles Businge Kaltrina Kutllovci-Hasani Andre P. Kengne Nandu Goswami Nandu Goswami Nandu Goswami
author_facet	Benedicta Ngwenchi Nkeh-Chungag Godwill Azeh Engwa Charles Businge Kaltrina Kutllovci-Hasani Andre P. Kengne Nandu Goswami Nandu Goswami Nandu Goswami
author_sort	Benedicta Ngwenchi Nkeh-Chungag
title	Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry
title_short	Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry
title_full	Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry
title_fullStr	Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry
title_full_unstemmed	Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry
title_sort	assessment of the cardiovascular risk profile of infants exposed to pre-eclampsia in-utero: a prospective case-control study in south african children of african ancestry
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5312118723974eddba8c03fe1df4ae45
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Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry

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