A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation

A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation

Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear. Here the authors follow TCR and show that a mobile endocytic network connects clathrin-independent receptor endocytosis...

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Auteurs principaux: Ewoud B. Compeer, Felix Kraus, Manuela Ecker, Gregory Redpath, Mayan Amiezer, Nils Rother, Philip R. Nicovich, Natasha Kapoor-Kaushik, Qiji Deng, Guerric P. B. Samson, Zhengmin Yang, Jieqiong Lou, Michael Carnell, Haig Vartoukian, Katharina Gaus, Jérémie Rossy
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
Q
Accès en ligne:https://doaj.org/article/5315f8de18a145b38208d17d8b1c2fbf
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Résumé:Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear. Here the authors follow TCR and show that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation.

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