Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to...

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Autores principales:	Elisabetta Zinellu, Angelo Zinellu, Maria Carmina Pau, Barbara Piras, Alessandro G. Fois, Sabrina Mellino, Ciriaco Carru, Arduino A. Mangoni, Pietro Pirina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic obstructive pulmonary disease oxidative stress antioxidant defense systems glutathione peroxidase Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5317ca2cc36d46c1ace45b0117ce040c
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spelling	oai:doaj.org-article:5317ca2cc36d46c1ace45b0117ce040c2021-11-25T16:27:42ZGlutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis10.3390/antiox101117452076-3921https://doaj.org/article/5317ca2cc36d46c1ace45b0117ce040c2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1745https://doaj.org/toc/2076-3921Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, <i>p</i> < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.Elisabetta ZinelluAngelo ZinelluMaria Carmina PauBarbara PirasAlessandro G. FoisSabrina MellinoCiriaco CarruArduino A. MangoniPietro PirinaMDPI AGarticlechronic obstructive pulmonary diseaseoxidative stressantioxidant defense systemsglutathione peroxidaseTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1745, p 1745 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic obstructive pulmonary disease oxidative stress antioxidant defense systems glutathione peroxidase Therapeutics. Pharmacology RM1-950
spellingShingle	chronic obstructive pulmonary disease oxidative stress antioxidant defense systems glutathione peroxidase Therapeutics. Pharmacology RM1-950 Elisabetta Zinellu Angelo Zinellu Maria Carmina Pau Barbara Piras Alessandro G. Fois Sabrina Mellino Ciriaco Carru Arduino A. Mangoni Pietro Pirina Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
description	Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, <i>p</i> < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.
format	article
author	Elisabetta Zinellu Angelo Zinellu Maria Carmina Pau Barbara Piras Alessandro G. Fois Sabrina Mellino Ciriaco Carru Arduino A. Mangoni Pietro Pirina
author_facet	Elisabetta Zinellu Angelo Zinellu Maria Carmina Pau Barbara Piras Alessandro G. Fois Sabrina Mellino Ciriaco Carru Arduino A. Mangoni Pietro Pirina
author_sort	Elisabetta Zinellu
title	Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_short	Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_full	Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_fullStr	Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_full_unstemmed	Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_sort	glutathione peroxidase in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5317ca2cc36d46c1ace45b0117ce040c
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Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

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