Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats

Hyperglycemia and hyperlipidemia-arbitrated mitochondrial oxidative insult is key reason for cardiac dysfunction and cardiomyopathy. Sinapic acid (SA) is a hydroxycinnamic acid (a polyphenolic acid) present in multiple plants and possesses several pharmacological activities. In this study, we examin...

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Autores principales:	Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mudassar Shahid, Khalid M. Alkharfy, Abdul Ahad, Mushtaq Ahmad Ansari, Ibrahim Abdelsalam Abdelrahman, Fahad I. Al-Jenoobi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Sinapic acid Streptozocin Cardiomyopathy Oxidative damage Nrf2/HO-1 and NF-κB Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/531822bcc7004823aec47add12f134d5
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spelling	oai:doaj.org-article:531822bcc7004823aec47add12f134d52021-11-12T04:25:41ZSinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats0753-332210.1016/j.biopha.2021.112412https://doaj.org/article/531822bcc7004823aec47add12f134d52022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011987https://doaj.org/toc/0753-3322Hyperglycemia and hyperlipidemia-arbitrated mitochondrial oxidative insult is key reason for cardiac dysfunction and cardiomyopathy. Sinapic acid (SA) is a hydroxycinnamic acid (a polyphenolic acid) present in multiple plants and possesses several pharmacological activities. In this study, we examined the cardio protective effects of SA on streptozotocin (STZ)-induced cardiac insults. STZ and both STZ induced diabetes and normal control rats were administered with 20 and 40 mg/kg SA for 12 weeks. STZ rats demonstrated hyperglycemia and hyperlipidemia. Additionally, STZ administered rats exhibited various histological changes in the cardiac muscles and significantly enhanced CK-MB and LDH. The significant enhancement of oxidative stress, inflammation, and apoptotic markers, and the capacity to curb oxidative stress was significantly abridged in the STZ induced diabetic heart. Chronic treatment with SA (20–40 mg/kg) ameliorated the increased level of glucose, lipid, and cardiac function markers and curtailed histological changes in the cardiac muscles. Chronic treatment also repressed inflammation, oxidative stress and apoptosis thereby and restoring antioxidant defenses in the myocardium of STZ induced diabetic rats. STZ induced cardiac dysfunction and cardiomyopathy by promoting inflammation and oxidative stress. Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy via improvement of hyperglycemia, hyperlipidemia, inflammation, oxidative stress, and apoptosis. Thus, SA possesses possible therapeutic value for the prevention of diabetic cardiac dysfunction and cardiomyopathy via the NRF2/HO-1 and NF-κB pathways.Mohammad RaishAjaz AhmadYousef A. Bin JardanMudassar ShahidKhalid M. AlkharfyAbdul AhadMushtaq Ahmad AnsariIbrahim Abdelsalam AbdelrahmanFahad I. Al-JenoobiElsevierarticleSinapic acidStreptozocinCardiomyopathyOxidative damageNrf2/HO-1 and NF-κBTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112412- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sinapic acid Streptozocin Cardiomyopathy Oxidative damage Nrf2/HO-1 and NF-κB Therapeutics. Pharmacology RM1-950
spellingShingle	Sinapic acid Streptozocin Cardiomyopathy Oxidative damage Nrf2/HO-1 and NF-κB Therapeutics. Pharmacology RM1-950 Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Mudassar Shahid Khalid M. Alkharfy Abdul Ahad Mushtaq Ahmad Ansari Ibrahim Abdelsalam Abdelrahman Fahad I. Al-Jenoobi Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
description	Hyperglycemia and hyperlipidemia-arbitrated mitochondrial oxidative insult is key reason for cardiac dysfunction and cardiomyopathy. Sinapic acid (SA) is a hydroxycinnamic acid (a polyphenolic acid) present in multiple plants and possesses several pharmacological activities. In this study, we examined the cardio protective effects of SA on streptozotocin (STZ)-induced cardiac insults. STZ and both STZ induced diabetes and normal control rats were administered with 20 and 40 mg/kg SA for 12 weeks. STZ rats demonstrated hyperglycemia and hyperlipidemia. Additionally, STZ administered rats exhibited various histological changes in the cardiac muscles and significantly enhanced CK-MB and LDH. The significant enhancement of oxidative stress, inflammation, and apoptotic markers, and the capacity to curb oxidative stress was significantly abridged in the STZ induced diabetic heart. Chronic treatment with SA (20–40 mg/kg) ameliorated the increased level of glucose, lipid, and cardiac function markers and curtailed histological changes in the cardiac muscles. Chronic treatment also repressed inflammation, oxidative stress and apoptosis thereby and restoring antioxidant defenses in the myocardium of STZ induced diabetic rats. STZ induced cardiac dysfunction and cardiomyopathy by promoting inflammation and oxidative stress. Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy via improvement of hyperglycemia, hyperlipidemia, inflammation, oxidative stress, and apoptosis. Thus, SA possesses possible therapeutic value for the prevention of diabetic cardiac dysfunction and cardiomyopathy via the NRF2/HO-1 and NF-κB pathways.
format	article
author	Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Mudassar Shahid Khalid M. Alkharfy Abdul Ahad Mushtaq Ahmad Ansari Ibrahim Abdelsalam Abdelrahman Fahad I. Al-Jenoobi
author_facet	Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Mudassar Shahid Khalid M. Alkharfy Abdul Ahad Mushtaq Ahmad Ansari Ibrahim Abdelsalam Abdelrahman Fahad I. Al-Jenoobi
author_sort	Mohammad Raish
title	Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
title_short	Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
title_full	Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
title_fullStr	Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
title_full_unstemmed	Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
title_sort	sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating nf-κb and nrf2/ho-1 signaling pathways in streptozocin induced diabetic rats
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/531822bcc7004823aec47add12f134d5
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Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats

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