Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats

Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats

Hyperglycemia and hyperlipidemia-arbitrated mitochondrial oxidative insult is key reason for cardiac dysfunction and cardiomyopathy. Sinapic acid (SA) is a hydroxycinnamic acid (a polyphenolic acid) present in multiple plants and possesses several pharmacological activities. In this study, we examin...

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Autores principales: Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mudassar Shahid, Khalid M. Alkharfy, Abdul Ahad, Mushtaq Ahmad Ansari, Ibrahim Abdelsalam Abdelrahman, Fahad I. Al-Jenoobi
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
Sinapic acid
Streptozocin
Cardiomyopathy
Oxidative damage
Nrf2/HO-1 and NF-κB
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/531822bcc7004823aec47add12f134d5
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