Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis

Drug-eluting stents (DES) are the gold standard for percutaneous coronary interventions (PCI); however, technical and anatomical challenges need to be addressed to ensure optimal apposition and prevent late adverse events. Complex vessel anatomies, including ectatic or aneurysmatic vessels, or signi...

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Autores principales:	Krzysztof Pujdak, Jan Kähler, Marc Werner
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5318c5ae0cd64891a9d6af3d45d0b970
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spelling	oai:doaj.org-article:5318c5ae0cd64891a9d6af3d45d0b9702021-12-04T16:03:35ZFeasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis10.15420/usc.2020.111758-390X1758-3896https://doaj.org/article/5318c5ae0cd64891a9d6af3d45d0b9702020-09-01T00:00:00Zhttps://www.uscjournal.com/articles/feasibility-safety-and-clinical-performancehttps://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XDrug-eluting stents (DES) are the gold standard for percutaneous coronary interventions (PCI); however, technical and anatomical challenges need to be addressed to ensure optimal apposition and prevent late adverse events. Complex vessel anatomies, including ectatic or aneurysmatic vessels, or significant differences in diameter in left main stenosis of the coronary artery, are clinical indications in which current PCI techniques attempt to shape conventional DES to follow vessel anatomy, thus modifying the original stent scaffold and its properties. However, due to their design, balloon-expandable cobalt–chromium and cobalt–nickel DES have limitations regarding their expansion capacity, which can result in undersizing and malapposition. New stent scaffolds have recently been introduced into clinical practice to address these challenging anatomies, including a drug-eluting nitinol stent platform. The nature of the nitinol device allows conformability to the native vessel, covering complex anatomies without manual adaptation. In this article, the authors present the rationale and current data on self-apposing nitinol DES in left main stenosis, and suggest that the device may be safely and effectively used with comparable rates of adverse cardiovascular events, as seen with second-generation balloon-expandable DES.Krzysztof PujdakJan KählerMarc WernerRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 14, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Krzysztof Pujdak Jan Kähler Marc Werner Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis
description	Drug-eluting stents (DES) are the gold standard for percutaneous coronary interventions (PCI); however, technical and anatomical challenges need to be addressed to ensure optimal apposition and prevent late adverse events. Complex vessel anatomies, including ectatic or aneurysmatic vessels, or significant differences in diameter in left main stenosis of the coronary artery, are clinical indications in which current PCI techniques attempt to shape conventional DES to follow vessel anatomy, thus modifying the original stent scaffold and its properties. However, due to their design, balloon-expandable cobalt–chromium and cobalt–nickel DES have limitations regarding their expansion capacity, which can result in undersizing and malapposition. New stent scaffolds have recently been introduced into clinical practice to address these challenging anatomies, including a drug-eluting nitinol stent platform. The nature of the nitinol device allows conformability to the native vessel, covering complex anatomies without manual adaptation. In this article, the authors present the rationale and current data on self-apposing nitinol DES in left main stenosis, and suggest that the device may be safely and effectively used with comparable rates of adverse cardiovascular events, as seen with second-generation balloon-expandable DES.
format	article
author	Krzysztof Pujdak Jan Kähler Marc Werner
author_facet	Krzysztof Pujdak Jan Kähler Marc Werner
author_sort	Krzysztof Pujdak
title	Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis
title_short	Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis
title_full	Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis
title_fullStr	Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis
title_full_unstemmed	Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis
title_sort	feasibility, safety, and clinical performance of self-apposing stents for left main stenosis
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/5318c5ae0cd64891a9d6af3d45d0b970
work_keys_str_mv	AT krzysztofpujdak feasibilitysafetyandclinicalperformanceofselfapposingstentsforleftmainstenosis AT jankahler feasibilitysafetyandclinicalperformanceofselfapposingstentsforleftmainstenosis AT marcwerner feasibilitysafetyandclinicalperformanceofselfapposingstentsforleftmainstenosis
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Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis

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