Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

Lauren Malave et al. examine the impact of sonic hedgehog signaling in the dorsal striatum in L-Dopa induced dyskinesia (LID) animal models. Their results suggest that increasing sonic hedgehog signaling can reduce the severity of LID and abnormal involuntary movements, suggesting future therapeutic...

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Autores principales:	Lauren Malave, Dustin R. Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas H. Kottmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/531a7bf6b9d14cf6b23b49f1fe99cc48
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spelling	oai:doaj.org-article:531a7bf6b9d14cf6b23b49f1fe99cc482021-12-02T17:26:48ZDopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia10.1038/s42003-021-02567-32399-3642https://doaj.org/article/531a7bf6b9d14cf6b23b49f1fe99cc482021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02567-3https://doaj.org/toc/2399-3642Lauren Malave et al. examine the impact of sonic hedgehog signaling in the dorsal striatum in L-Dopa induced dyskinesia (LID) animal models. Their results suggest that increasing sonic hedgehog signaling can reduce the severity of LID and abnormal involuntary movements, suggesting future therapeutic approaches to mitigate dyskinetic comorbidities of long-term treatment with L-Dopa.Lauren MalaveDustin R. ZuelkeSantiago Uribe-CanoLev StarikovHeike RebholzEitan FriedmanChuan QinQin LiErwan BezardAndreas H. KottmannNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lauren Malave Dustin R. Zuelke Santiago Uribe-Cano Lev Starikov Heike Rebholz Eitan Friedman Chuan Qin Qin Li Erwan Bezard Andreas H. Kottmann Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
description	Lauren Malave et al. examine the impact of sonic hedgehog signaling in the dorsal striatum in L-Dopa induced dyskinesia (LID) animal models. Their results suggest that increasing sonic hedgehog signaling can reduce the severity of LID and abnormal involuntary movements, suggesting future therapeutic approaches to mitigate dyskinetic comorbidities of long-term treatment with L-Dopa.
format	article
author	Lauren Malave Dustin R. Zuelke Santiago Uribe-Cano Lev Starikov Heike Rebholz Eitan Friedman Chuan Qin Qin Li Erwan Bezard Andreas H. Kottmann
author_facet	Lauren Malave Dustin R. Zuelke Santiago Uribe-Cano Lev Starikov Heike Rebholz Eitan Friedman Chuan Qin Qin Li Erwan Bezard Andreas H. Kottmann
author_sort	Lauren Malave
title	Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
title_short	Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
title_full	Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
title_fullStr	Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
title_full_unstemmed	Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
title_sort	dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of parkinson’s disease and l-dopa induced dyskinesia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/531a7bf6b9d14cf6b23b49f1fe99cc48
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Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

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