Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation

Abstract The land snail Ellobium chinense (L. Pfeiffer, 1855) (Eupulmonata, Ellobiida, Ellobiidae), which inhabits the salt marshes along the coastal areas of northwestern Pacific, is an endangered species on the IUCN Red List. Over recent decades, the population size of E. chinense has consistently...

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Autores principales:	Cho Rong Shin, Eun Hwa Choi, Gyeongmin Kim, Su Youn Baek, Bia Park, Jihye Hwang, Jumin Jun, Hyun Jong Kil, Hyunkyung Oh, Kyungjin Lee, Sa Heung Kim, Jongrak Lee, Seung Jik Suh, Dong-min Park, Ho Young Suk, Yong Seok Lee, Young Sup Lee, Ui Wook Hwang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5323a3d24c9d4a88b11a1ff615e0a991
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spelling	oai:doaj.org-article:5323a3d24c9d4a88b11a1ff615e0a9912021-12-02T17:52:41ZCharacterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation10.1038/s41598-021-91675-52045-2322https://doaj.org/article/5323a3d24c9d4a88b11a1ff615e0a9912021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91675-5https://doaj.org/toc/2045-2322Abstract The land snail Ellobium chinense (L. Pfeiffer, 1855) (Eupulmonata, Ellobiida, Ellobiidae), which inhabits the salt marshes along the coastal areas of northwestern Pacific, is an endangered species on the IUCN Red List. Over recent decades, the population size of E. chinense has consistently decreased due to environmental interference caused by natural disasters and human activities. Here, we provide the first assessment of the genetic diversity and population genetic structures of northwestern Pacific E. chinense. The results analyzed with COI and microsatellites revealed that E. chinense population exhibit metapopulation characteristics, retaining under the influence of the Kuroshio warm currents through expansion of the Late-Middle and Late Pleistocene. We also found four phylogenetic groups, regardless of geographical distributions, which were easily distinguishable by four unidirectional and stepwise adenine-to-guanine transitions in COI (sites 207–282–354–420: A–A–A–A, A–A–G–A, G–A–G–A, and G–G–G–G). Additionally, the four COI hotspots were robustly connected with a high degree of covariance between them. We discuss the role of these covariate guanines which link to form four consecutive G-quadruplexes, and their possible beneficial effects under positive selection pressure.Cho Rong ShinEun Hwa ChoiGyeongmin KimSu Youn BaekBia ParkJihye HwangJumin JunHyun Jong KilHyunkyung OhKyungjin LeeSa Heung KimJongrak LeeSeung Jik SuhDong-min ParkHo Young SukYong Seok LeeYoung Sup LeeUi Wook HwangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cho Rong Shin Eun Hwa Choi Gyeongmin Kim Su Youn Baek Bia Park Jihye Hwang Jumin Jun Hyun Jong Kil Hyunkyung Oh Kyungjin Lee Sa Heung Kim Jongrak Lee Seung Jik Suh Dong-min Park Ho Young Suk Yong Seok Lee Young Sup Lee Ui Wook Hwang Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation
description	Abstract The land snail Ellobium chinense (L. Pfeiffer, 1855) (Eupulmonata, Ellobiida, Ellobiidae), which inhabits the salt marshes along the coastal areas of northwestern Pacific, is an endangered species on the IUCN Red List. Over recent decades, the population size of E. chinense has consistently decreased due to environmental interference caused by natural disasters and human activities. Here, we provide the first assessment of the genetic diversity and population genetic structures of northwestern Pacific E. chinense. The results analyzed with COI and microsatellites revealed that E. chinense population exhibit metapopulation characteristics, retaining under the influence of the Kuroshio warm currents through expansion of the Late-Middle and Late Pleistocene. We also found four phylogenetic groups, regardless of geographical distributions, which were easily distinguishable by four unidirectional and stepwise adenine-to-guanine transitions in COI (sites 207–282–354–420: A–A–A–A, A–A–G–A, G–A–G–A, and G–G–G–G). Additionally, the four COI hotspots were robustly connected with a high degree of covariance between them. We discuss the role of these covariate guanines which link to form four consecutive G-quadruplexes, and their possible beneficial effects under positive selection pressure.
format	article
author	Cho Rong Shin Eun Hwa Choi Gyeongmin Kim Su Youn Baek Bia Park Jihye Hwang Jumin Jun Hyun Jong Kil Hyunkyung Oh Kyungjin Lee Sa Heung Kim Jongrak Lee Seung Jik Suh Dong-min Park Ho Young Suk Yong Seok Lee Young Sup Lee Ui Wook Hwang
author_facet	Cho Rong Shin Eun Hwa Choi Gyeongmin Kim Su Youn Baek Bia Park Jihye Hwang Jumin Jun Hyun Jong Kil Hyunkyung Oh Kyungjin Lee Sa Heung Kim Jongrak Lee Seung Jik Suh Dong-min Park Ho Young Suk Yong Seok Lee Young Sup Lee Ui Wook Hwang
author_sort	Cho Rong Shin
title	Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation
title_short	Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation
title_full	Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation
title_fullStr	Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation
title_full_unstemmed	Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation
title_sort	characterization of metapopulation of ellobium chinense through pleistocene expansions and four covariate coi guanine-hotspots linked to g-quadruplex conformation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5323a3d24c9d4a88b11a1ff615e0a991
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Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation

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