Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations

Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respecti...

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Autores principales:	Elena Vital'evna Titovich, Tamara Leonidovna Kuraeva, G I Danilova, L P Alekseev, M N Boldyreva, A N Nikitin, O N Ivanova, Sergey Alexandrovich Prokofiev, Lyubov' Iosifovna Zilberman, N M Tsitlidze, Valery Vyacheslavovich Nosikov, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 1 diabetes mellitus polymorphism of class ii hla genes population studies Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5323be91c99544c4a6a3e858d767d171
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spelling	oai:doaj.org-article:5323be91c99544c4a6a3e858d767d1712021-11-14T09:00:14ZAssociation of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations2072-03512072-037810.14341/2072-0351-5448https://doaj.org/article/5323be91c99544c4a6a3e858d767d1712009-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5448https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB117(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB10304 in the Moscow population (RR=8,94). The presence of DRB104, DRB117(03), DQA10301, DQB10201, and DQB10302 accountedfor RR >2 in both populations. Only two alleles, DRB104 and DRB17(03), in the Yakutian population and five of the six (DRB104,DRB117(03), DQA1(0301), DQB10302, and DQB10304) in the Moscow one were closely associated with DM1 (RR >4). DRB109, DRB111,DQB113, DQB10602/8 in Yakutian and DRB111, DRB113, DQA10103, DQB10301, DQB10602/8 in Moscow populations had the highestprotective potential (RRElena Vital'evna TitovichTamara Leonidovna KuraevaG I DanilovaL P AlekseevM N BoldyrevaA N NikitinO N IvanovaSergey Alexandrovich ProkofievLyubov' Iosifovna ZilbermanN M TsitlidzeValery Vyacheslavovich NosikovIvan Ivanovich DedovEndocrinology Research Centrearticletype 1 diabetes mellituspolymorphism of class ii hla genespopulation studiesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 3, Pp 26-32 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus polymorphism of class ii hla genes population studies Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus polymorphism of class ii hla genes population studies Nutritional diseases. Deficiency diseases RC620-627 Elena Vital'evna Titovich Tamara Leonidovna Kuraeva G I Danilova L P Alekseev M N Boldyreva A N Nikitin O N Ivanova Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman N M Tsitlidze Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
description	Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB117(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB10304 in the Moscow population (RR=8,94). The presence of DRB104, DRB117(03), DQA10301, DQB10201, and DQB10302 accountedfor RR >2 in both populations. Only two alleles, DRB104 and DRB17(03), in the Yakutian population and five of the six (DRB104,DRB117(03), DQA1(0301), DQB10302, and DQB10304) in the Moscow one were closely associated with DM1 (RR >4). DRB109, DRB111,DQB113, DQB10602/8 in Yakutian and DRB111, DRB113, DQA10103, DQB10301, DQB10602/8 in Moscow populations had the highestprotective potential (RR
format	article
author	Elena Vital'evna Titovich Tamara Leonidovna Kuraeva G I Danilova L P Alekseev M N Boldyreva A N Nikitin O N Ivanova Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman N M Tsitlidze Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov
author_facet	Elena Vital'evna Titovich Tamara Leonidovna Kuraeva G I Danilova L P Alekseev M N Boldyreva A N Nikitin O N Ivanova Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman N M Tsitlidze Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov
author_sort	Elena Vital'evna Titovich
title	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
title_short	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
title_full	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
title_fullStr	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
title_full_unstemmed	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
title_sort	association of type 1 diabetes mellitus (dm1) with polymorphous alleles of class ii hla genes in yakutian and russian populations
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/5323be91c99544c4a6a3e858d767d171
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Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations

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