The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lydia Kasper, Annika König, Paul-Albert Koenig, Mark S. Gresnigt, Johannes Westman, Rebecca A. Drummond, Michail S. Lionakis, Olaf Groß, Jürgen Ruland, Julian R. Naglik, Bernhard Hube
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5324ba10a64d4c6bbae3366e1c0cfbac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5324ba10a64d4c6bbae3366e1c0cfbac
record_format	dspace
spelling	oai:doaj.org-article:5324ba10a64d4c6bbae3366e1c0cfbac2021-12-02T15:34:39ZThe fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes10.1038/s41467-018-06607-12041-1723https://doaj.org/article/5324ba10a64d4c6bbae3366e1c0cfbac2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06607-1https://doaj.org/toc/2041-1723Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger of NLRP3 inflammasome activation in these cells.Lydia KasperAnnika KönigPaul-Albert KoenigMark S. GresnigtJohannes WestmanRebecca A. DrummondMichail S. LionakisOlaf GroßJürgen RulandJulian R. NaglikBernhard HubeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lydia Kasper Annika König Paul-Albert Koenig Mark S. Gresnigt Johannes Westman Rebecca A. Drummond Michail S. Lionakis Olaf Groß Jürgen Ruland Julian R. Naglik Bernhard Hube The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
description	Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger of NLRP3 inflammasome activation in these cells.
format	article
author	Lydia Kasper Annika König Paul-Albert Koenig Mark S. Gresnigt Johannes Westman Rebecca A. Drummond Michail S. Lionakis Olaf Groß Jürgen Ruland Julian R. Naglik Bernhard Hube
author_facet	Lydia Kasper Annika König Paul-Albert Koenig Mark S. Gresnigt Johannes Westman Rebecca A. Drummond Michail S. Lionakis Olaf Groß Jürgen Ruland Julian R. Naglik Bernhard Hube
author_sort	Lydia Kasper
title	The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
title_short	The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
title_full	The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
title_fullStr	The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
title_full_unstemmed	The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
title_sort	fungal peptide toxin candidalysin activates the nlrp3 inflammasome and causes cytolysis in mononuclear phagocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5324ba10a64d4c6bbae3366e1c0cfbac
work_keys_str_mv	AT lydiakasper thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT annikakonig thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT paulalbertkoenig thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT marksgresnigt thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT johanneswestman thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT rebeccaadrummond thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT michailslionakis thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT olafgroß thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT jurgenruland thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT julianrnaglik thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT bernhardhube thefungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT lydiakasper fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT annikakonig fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT paulalbertkoenig fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT marksgresnigt fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT johanneswestman fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT rebeccaadrummond fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT michailslionakis fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT olafgroß fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT jurgenruland fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT julianrnaglik fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes AT bernhardhube fungalpeptidetoxincandidalysinactivatesthenlrp3inflammasomeandcausescytolysisinmononuclearphagocytes
_version_	1718386781152346112

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Ejemplares similares