Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma
Abstract The exon 19 and 21 in Epidermal Growth Factor Receptor (EGFR) mutation are the most common subtype of lung adenocarcinoma, and the strongest predictive biomarker for progression-free survival and tumor response. Although some studies have shown differences in radiological features between c...
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Nature Portfolio
2017
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oai:doaj.org-article:5325000073d944fb9657e0dd84f324872021-12-02T12:32:04ZRadiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma10.1038/s41598-017-00511-22045-2322https://doaj.org/article/5325000073d944fb9657e0dd84f324872017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00511-2https://doaj.org/toc/2045-2322Abstract The exon 19 and 21 in Epidermal Growth Factor Receptor (EGFR) mutation are the most common subtype of lung adenocarcinoma, and the strongest predictive biomarker for progression-free survival and tumor response. Although some studies have shown differences in radiological features between cases with and without EFGR mutations, they lacked necessary stratification. This article is to evaluate the association of CT features between the wild type and the subtype (exon 19 and 21) of EGFR mutations in patients with lung adenocarcinoma. Of the 721 finally included patients, 132 were positive for EGFR mutation in exon 19, 140 were positive for EGFR mutation in exon 21, and 449 were EGFR wild type. EGFR mutation in exon 19 was associated with a small-maximum diameter (28.51 ± 14.07) (p < 0.0001); sex (p < 0.0001); pleural retraction (p = 0.0034); and the absence of fibrosis (p < 0.0001), while spiculated margins (p = 0.0095), subsolid density (p < 0.0001) and no smoking (p < 0.0001) were associated with EGFR mutation in exon 21. Receiver Operating Characteristic (ROC) curves suggested that the maximum Area Under the Curve (AUC) was related to the female gender (AUC = 0.636) and the absence of smoking (AUC = 0.681). This study demonstrated the radiological and clinical features could be used to prognosticate EGFR mutation subtypes in exon 19 and 21.Zhang ShiXuan ZhengRuifeng ShiChangen SongRunhong YangQianwen ZhangXinrui WangJianping LuYongwei YuQi LiuTao JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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Medicine R Science Q Zhang Shi Xuan Zheng Ruifeng Shi Changen Song Runhong Yang Qianwen Zhang Xinrui Wang Jianping Lu Yongwei Yu Qi Liu Tao Jiang Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma |
| description |
Abstract The exon 19 and 21 in Epidermal Growth Factor Receptor (EGFR) mutation are the most common subtype of lung adenocarcinoma, and the strongest predictive biomarker for progression-free survival and tumor response. Although some studies have shown differences in radiological features between cases with and without EFGR mutations, they lacked necessary stratification. This article is to evaluate the association of CT features between the wild type and the subtype (exon 19 and 21) of EGFR mutations in patients with lung adenocarcinoma. Of the 721 finally included patients, 132 were positive for EGFR mutation in exon 19, 140 were positive for EGFR mutation in exon 21, and 449 were EGFR wild type. EGFR mutation in exon 19 was associated with a small-maximum diameter (28.51 ± 14.07) (p < 0.0001); sex (p < 0.0001); pleural retraction (p = 0.0034); and the absence of fibrosis (p < 0.0001), while spiculated margins (p = 0.0095), subsolid density (p < 0.0001) and no smoking (p < 0.0001) were associated with EGFR mutation in exon 21. Receiver Operating Characteristic (ROC) curves suggested that the maximum Area Under the Curve (AUC) was related to the female gender (AUC = 0.636) and the absence of smoking (AUC = 0.681). This study demonstrated the radiological and clinical features could be used to prognosticate EGFR mutation subtypes in exon 19 and 21. |
| format |
article |
| author |
Zhang Shi Xuan Zheng Ruifeng Shi Changen Song Runhong Yang Qianwen Zhang Xinrui Wang Jianping Lu Yongwei Yu Qi Liu Tao Jiang |
| author_facet |
Zhang Shi Xuan Zheng Ruifeng Shi Changen Song Runhong Yang Qianwen Zhang Xinrui Wang Jianping Lu Yongwei Yu Qi Liu Tao Jiang |
| author_sort |
Zhang Shi |
| title |
Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma |
| title_short |
Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma |
| title_full |
Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma |
| title_fullStr |
Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma |
| title_full_unstemmed |
Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma |
| title_sort |
radiological and clinical features associated with epidermal growth factor receptor mutation status of exon 19 and 21 in lung adenocarcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/5325000073d944fb9657e0dd84f32487 |
| work_keys_str_mv |
AT zhangshi radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT xuanzheng radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT ruifengshi radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT changensong radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT runhongyang radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT qianwenzhang radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT xinruiwang radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT jianpinglu radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT yongweiyu radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT qiliu radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma AT taojiang radiologicalandclinicalfeaturesassociatedwithepidermalgrowthfactorreceptormutationstatusofexon19and21inlungadenocarcinoma |
| _version_ |
1718394154977853440 |