Endogenous antisense RNA curbs CD39 expression in Crohn’s disease

CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration of pathology in an animal model of colitis.

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Autores principales:	Rasika P. Harshe, Anyan Xie, Marta Vuerich, Luiza Abrahão Frank, Barbora Gromova, Haohai Zhang, Rene’ J. Robles, Samiran Mukherjee, Eva Csizmadia, Efi Kokkotou, Adam S. Cheifetz, Alan C. Moss, Satya K. Kota, Simon C. Robson, Maria Serena Longhi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53270d85737b4225a98e857f58c20b7a
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spelling	oai:doaj.org-article:53270d85737b4225a98e857f58c20b7a2021-12-02T14:42:13ZEndogenous antisense RNA curbs CD39 expression in Crohn’s disease10.1038/s41467-020-19692-y2041-1723https://doaj.org/article/53270d85737b4225a98e857f58c20b7a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19692-yhttps://doaj.org/toc/2041-1723CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration of pathology in an animal model of colitis.Rasika P. HarsheAnyan XieMarta VuerichLuiza Abrahão FrankBarbora GromovaHaohai ZhangRene’ J. RoblesSamiran MukherjeeEva CsizmadiaEfi KokkotouAdam S. CheifetzAlan C. MossSatya K. KotaSimon C. RobsonMaria Serena LonghiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rasika P. Harshe Anyan Xie Marta Vuerich Luiza Abrahão Frank Barbora Gromova Haohai Zhang Rene’ J. Robles Samiran Mukherjee Eva Csizmadia Efi Kokkotou Adam S. Cheifetz Alan C. Moss Satya K. Kota Simon C. Robson Maria Serena Longhi Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
description	CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration of pathology in an animal model of colitis.
format	article
author	Rasika P. Harshe Anyan Xie Marta Vuerich Luiza Abrahão Frank Barbora Gromova Haohai Zhang Rene’ J. Robles Samiran Mukherjee Eva Csizmadia Efi Kokkotou Adam S. Cheifetz Alan C. Moss Satya K. Kota Simon C. Robson Maria Serena Longhi
author_facet	Rasika P. Harshe Anyan Xie Marta Vuerich Luiza Abrahão Frank Barbora Gromova Haohai Zhang Rene’ J. Robles Samiran Mukherjee Eva Csizmadia Efi Kokkotou Adam S. Cheifetz Alan C. Moss Satya K. Kota Simon C. Robson Maria Serena Longhi
author_sort	Rasika P. Harshe
title	Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
title_short	Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
title_full	Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
title_fullStr	Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
title_full_unstemmed	Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
title_sort	endogenous antisense rna curbs cd39 expression in crohn’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/53270d85737b4225a98e857f58c20b7a
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Endogenous antisense RNA curbs CD39 expression in Crohn’s disease

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