UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes

Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma). We reviewed the state of knowledge of the damaging action of UVB and UVA on DN...

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Autores principales:	Yuliya L. Vechtomova, Taisiya A. Telegina, Andrey A. Buglak, Mikhail S. Kritsky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNA repair cancer ultraviolet ROS DNA-photolyase cryptochrome Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5327bea810c849db8cf724a7aac4890b
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id	oai:doaj.org-article:5327bea810c849db8cf724a7aac4890b
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spelling	oai:doaj.org-article:5327bea810c849db8cf724a7aac4890b2021-11-25T16:49:04ZUV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes10.3390/biomedicines91115642227-9059https://doaj.org/article/5327bea810c849db8cf724a7aac4890b2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1564https://doaj.org/toc/2227-9059Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma). We reviewed the state of knowledge of the damaging action of UVB and UVA on DNA, and also the mechanisms of DNA repair with the participation of the DNA-photolyase enzyme or of the nucleotide excision repair (NER) system. In the course of evolution, most mammals lost the possibility of DNA photoreparation due to the disappearance of DNA photolyase genes, but they retained closely related cryptochromes that regulate the transcription of the NER system enzymes. We analyze the published relationships between DNA photolyases/cryptochromes and carcinogenesis, as well as their possible role in the prevention and treatment of diseases caused by UV radiation.Yuliya L. VechtomovaTaisiya A. TeleginaAndrey A. BuglakMikhail S. KritskyMDPI AGarticleDNA repaircancerultravioletROSDNA-photolyasecryptochromeBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1564, p 1564 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA repair cancer ultraviolet ROS DNA-photolyase cryptochrome Biology (General) QH301-705.5
spellingShingle	DNA repair cancer ultraviolet ROS DNA-photolyase cryptochrome Biology (General) QH301-705.5 Yuliya L. Vechtomova Taisiya A. Telegina Andrey A. Buglak Mikhail S. Kritsky UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
description	Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma). We reviewed the state of knowledge of the damaging action of UVB and UVA on DNA, and also the mechanisms of DNA repair with the participation of the DNA-photolyase enzyme or of the nucleotide excision repair (NER) system. In the course of evolution, most mammals lost the possibility of DNA photoreparation due to the disappearance of DNA photolyase genes, but they retained closely related cryptochromes that regulate the transcription of the NER system enzymes. We analyze the published relationships between DNA photolyases/cryptochromes and carcinogenesis, as well as their possible role in the prevention and treatment of diseases caused by UV radiation.
format	article
author	Yuliya L. Vechtomova Taisiya A. Telegina Andrey A. Buglak Mikhail S. Kritsky
author_facet	Yuliya L. Vechtomova Taisiya A. Telegina Andrey A. Buglak Mikhail S. Kritsky
author_sort	Yuliya L. Vechtomova
title	UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
title_short	UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
title_full	UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
title_fullStr	UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
title_full_unstemmed	UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
title_sort	uv radiation in dna damage and repair involving dna-photolyases and cryptochromes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5327bea810c849db8cf724a7aac4890b
work_keys_str_mv	AT yuliyalvechtomova uvradiationindnadamageandrepairinvolvingdnaphotolyasesandcryptochromes AT taisiyaatelegina uvradiationindnadamageandrepairinvolvingdnaphotolyasesandcryptochromes AT andreyabuglak uvradiationindnadamageandrepairinvolvingdnaphotolyasesandcryptochromes AT mikhailskritsky uvradiationindnadamageandrepairinvolvingdnaphotolyasesandcryptochromes
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UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes

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