Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insights into the function of Rix7 as a molecular unfoldase...

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Autores principales:	Yu-Hua Lo, Mack Sobhany, Allen L. Hsu, Brittany L. Ford, Juno M. Krahn, Mario J. Borgnia, Robin E. Stanley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/532b14f2bbab448784ac75464a65da1f
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spelling	oai:doaj.org-article:532b14f2bbab448784ac75464a65da1f2021-12-02T14:39:38ZCryo-EM structure of the essential ribosome assembly AAA-ATPase Rix710.1038/s41467-019-08373-02041-1723https://doaj.org/article/532b14f2bbab448784ac75464a65da1f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08373-0https://doaj.org/toc/2041-1723Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insights into the function of Rix7 as a molecular unfoldase.Yu-Hua LoMack SobhanyAllen L. HsuBrittany L. FordJuno M. KrahnMario J. BorgniaRobin E. StanleyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Hua Lo Mack Sobhany Allen L. Hsu Brittany L. Ford Juno M. Krahn Mario J. Borgnia Robin E. Stanley Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
description	Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insights into the function of Rix7 as a molecular unfoldase.
format	article
author	Yu-Hua Lo Mack Sobhany Allen L. Hsu Brittany L. Ford Juno M. Krahn Mario J. Borgnia Robin E. Stanley
author_facet	Yu-Hua Lo Mack Sobhany Allen L. Hsu Brittany L. Ford Juno M. Krahn Mario J. Borgnia Robin E. Stanley
author_sort	Yu-Hua Lo
title	Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
title_short	Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
title_full	Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
title_fullStr	Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
title_full_unstemmed	Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
title_sort	cryo-em structure of the essential ribosome assembly aaa-atpase rix7
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/532b14f2bbab448784ac75464a65da1f
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Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

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