SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA

Abstract. A study of leukocyte regulation system in patients with exacerbated bronchial asthma (BA) was performed by means of measuring spontaneous and induced production of certain cytokines (IL-4, IL-1b, IL-10 and IFNg) in whole blood, and drawing some specific coefficients reflecting production o...

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Autores principales:	L. V. Ryabova, A. V. Zurochka
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bronchial asthma cytokines il-4 il-1 il-10 ifn Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/532e3d98a445465b86a0136047ed164e
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spelling	oai:doaj.org-article:532e3d98a445465b86a0136047ed164e2021-11-18T08:03:39ZSPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2007-4-5-493-498https://doaj.org/article/532e3d98a445465b86a0136047ed164e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/222https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A study of leukocyte regulation system in patients with exacerbated bronchial asthma (BA) was performed by means of measuring spontaneous and induced production of certain cytokines (IL-4, IL-1b, IL-10 and IFNg) in whole blood, and drawing some specific coefficients reflecting production of the cytokines, as compared to control values. Group 1 consisted of mixed-type BA patients, with mild clinical manifestations at exacerbation stage. A control group included twelve healthy persons. The cytokine network was evaluated according to spontaneous production of cytokines (IL-4, IL-1b, IL-10 and IFNg), or their induction with standard mitogens (PHA and E. coli LPS). The results obtained have shown that in BA as a clinical model of chronic inflammation, synthesis and activation of the cytokines depend on the phase of disease. At stage of exacerbation, an imbalance occurs between pro- and anti-inflammatory cytokines, with predominance of anti-inflammatory IL-10, which is targeted to suppression of bronchial inflammation.L. V. RyabovaA. V. ZurochkaSPb RAACIarticlebronchial asthmacytokinesil-4il-1il-10ifnImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 493-498 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma cytokines il-4 il-1 il-10 ifn Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma cytokines il-4 il-1 il-10 ifn Immunologic diseases. Allergy RC581-607 L. V. Ryabova A. V. Zurochka SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
description	Abstract. A study of leukocyte regulation system in patients with exacerbated bronchial asthma (BA) was performed by means of measuring spontaneous and induced production of certain cytokines (IL-4, IL-1b, IL-10 and IFNg) in whole blood, and drawing some specific coefficients reflecting production of the cytokines, as compared to control values. Group 1 consisted of mixed-type BA patients, with mild clinical manifestations at exacerbation stage. A control group included twelve healthy persons. The cytokine network was evaluated according to spontaneous production of cytokines (IL-4, IL-1b, IL-10 and IFNg), or their induction with standard mitogens (PHA and E. coli LPS). The results obtained have shown that in BA as a clinical model of chronic inflammation, synthesis and activation of the cytokines depend on the phase of disease. At stage of exacerbation, an imbalance occurs between pro- and anti-inflammatory cytokines, with predominance of anti-inflammatory IL-10, which is targeted to suppression of bronchial inflammation.
format	article
author	L. V. Ryabova A. V. Zurochka
author_facet	L. V. Ryabova A. V. Zurochka
author_sort	L. V. Ryabova
title	SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
title_short	SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
title_full	SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
title_fullStr	SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
title_full_unstemmed	SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
title_sort	specific stage-dependent features of cytokine cascade in the patients with bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/532e3d98a445465b86a0136047ed164e
work_keys_str_mv	AT lvryabova specificstagedependentfeaturesofcytokinecascadeinthepatientswithbronchialasthma AT avzurochka specificstagedependentfeaturesofcytokinecascadeinthepatientswithbronchialasthma
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SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA

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