Protect Effects of Seafood-Derived Plasmalogens Against Amyloid-Beta (1–42) Induced Toxicity via Modulating the Transcripts Related to Endocytosis, Autophagy, Apoptosis, Neurotransmitter Release and Synaptic Transmission in SH-SY5Y Cells

Protect Effects of Seafood-Derived Plasmalogens Against Amyloid-Beta (1–42) Induced Toxicity via Modulating the Transcripts Related to Endocytosis, Autophagy, Apoptosis, Neurotransmitter Release and Synaptic Transmission in SH-SY5Y Cells

To investigate the underlying mechanisms of decreased plasmalogens (Pls) levels in neurodegenerative diseases, here the effects of seafood-derived Pls on undifferentiated and differentiated human SH-SY5Y neuroblastoma cells exposed to amyloid-β1–42 was analyzed. Transcriptional profiles indicated th...

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Bibliographic Details
Main Authors: Junli Feng, Gongshuai Song, Qing Shen, Xi Chen, Qingcheng Wang, Shunyuan Guo, Manman Zhang
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
Alzheimer’s disease
plasmalogens
SH-SY5Y cells
gene expression
transcriptional profiles
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Online Access:https://doaj.org/article/532e638f68444a3c99fc0143f18f40db
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