Biomimetic nanoparticles: preparation, characterization and biomedical applications
Ana Maria Carmona-RibeiroBiocolloids Lab, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, BrazilAbstract: Mimicking nature is a powerful approach for developing novel lipid-based devices for drug and...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2010
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/532fda38426f4a16bfb370b95fe264f6 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:532fda38426f4a16bfb370b95fe264f6 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:532fda38426f4a16bfb370b95fe264f62021-12-02T01:08:07ZBiomimetic nanoparticles: preparation, characterization and biomedical applications1176-91141178-2013https://doaj.org/article/532fda38426f4a16bfb370b95fe264f62010-04-01T00:00:00Zhttp://www.dovepress.com/biomimetic-nanoparticles-preparation-characterization-and-biomedical-a-a4200https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ana Maria Carmona-RibeiroBiocolloids Lab, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, BrazilAbstract: Mimicking nature is a powerful approach for developing novel lipid-based devices for drug and vaccine delivery. In this review, biomimetic assemblies based on natural or synthetic lipids by themselves or associated to silica, latex or drug particles will be discussed. In water, self-assembly of lipid molecules into supramolecular structures is fairly well understood. However, their self-assembly on a solid surface or at an interface remains poorly understood. In certain cases, hydrophobic drug granules can be dispersed in aqueous solution via lipid adsorption surrounding the drug particles as nanocapsules. In other instances, hydrophobic drug molecules attach as monomers to borders of lipid bilayer fragments providing drug formulations that are effective in vivo at low drug-to-lipid-molar ratio. Cationic biomimetic particles offer suitable interfacial environment for adsorption, presentation and targeting of biomolecules in vivo. Thereby antigens can effectively be presented by tailored biomimetic particles for development of vaccines over a range of defined and controllable particle sizes. Biomolecular recognition between receptor and ligand can be reconstituted by means of receptor immobilization into supported lipidic bilayers allowing isolation and characterization of signal transduction steps.Keywords: cationic lipid, phospholipids, bilayer fragments, vesicles, silica, polymeric particles, antigens, novel cationic immunoadjuvants, drugs Ana Maria Carmona-RibeiroDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 249-259 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Ana Maria Carmona-Ribeiro Biomimetic nanoparticles: preparation, characterization and biomedical applications |
| description |
Ana Maria Carmona-RibeiroBiocolloids Lab, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, BrazilAbstract: Mimicking nature is a powerful approach for developing novel lipid-based devices for drug and vaccine delivery. In this review, biomimetic assemblies based on natural or synthetic lipids by themselves or associated to silica, latex or drug particles will be discussed. In water, self-assembly of lipid molecules into supramolecular structures is fairly well understood. However, their self-assembly on a solid surface or at an interface remains poorly understood. In certain cases, hydrophobic drug granules can be dispersed in aqueous solution via lipid adsorption surrounding the drug particles as nanocapsules. In other instances, hydrophobic drug molecules attach as monomers to borders of lipid bilayer fragments providing drug formulations that are effective in vivo at low drug-to-lipid-molar ratio. Cationic biomimetic particles offer suitable interfacial environment for adsorption, presentation and targeting of biomolecules in vivo. Thereby antigens can effectively be presented by tailored biomimetic particles for development of vaccines over a range of defined and controllable particle sizes. Biomolecular recognition between receptor and ligand can be reconstituted by means of receptor immobilization into supported lipidic bilayers allowing isolation and characterization of signal transduction steps.Keywords: cationic lipid, phospholipids, bilayer fragments, vesicles, silica, polymeric particles, antigens, novel cationic immunoadjuvants, drugs |
| format |
article |
| author |
Ana Maria Carmona-Ribeiro |
| author_facet |
Ana Maria Carmona-Ribeiro |
| author_sort |
Ana Maria Carmona-Ribeiro |
| title |
Biomimetic nanoparticles: preparation, characterization and biomedical applications |
| title_short |
Biomimetic nanoparticles: preparation, characterization and biomedical applications |
| title_full |
Biomimetic nanoparticles: preparation, characterization and biomedical applications |
| title_fullStr |
Biomimetic nanoparticles: preparation, characterization and biomedical applications |
| title_full_unstemmed |
Biomimetic nanoparticles: preparation, characterization and biomedical applications |
| title_sort |
biomimetic nanoparticles: preparation, characterization and biomedical applications |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/532fda38426f4a16bfb370b95fe264f6 |
| work_keys_str_mv |
AT anamariacarmonaribeiro biomimeticnanoparticlespreparationcharacterizationandbiomedicalapplications |
| _version_ |
1718403254682910720 |