Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.

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Autores principales:	Kevin Wittwer, Danielle E. Anderson, Kristin Pfeffermann, Robert M. Cox, Josef D. Wolf, Sabine Santibanez, Annette Mankertz, Roland Plesker, Zachary M. Sticher, Alexander A. Kolkykhalov, Michael G. Natchus, Christian K. Pfaller, Richard K. Plemper, Veronika von Messling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5330f59bd9fe43ada6a0147032c636eb
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spelling	oai:doaj.org-article:5330f59bd9fe43ada6a0147032c636eb2021-12-02T19:04:01ZSmall-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding10.1038/s41467-021-25497-42041-1723https://doaj.org/article/5330f59bd9fe43ada6a0147032c636eb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25497-4https://doaj.org/toc/2041-1723Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.Kevin WittwerDanielle E. AndersonKristin PfeffermannRobert M. CoxJosef D. WolfSabine SantibanezAnnette MankertzRoland PleskerZachary M. SticherAlexander A. KolkykhalovMichael G. NatchusChristian K. PfallerRichard K. PlemperVeronika von MesslingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Wittwer Danielle E. Anderson Kristin Pfeffermann Robert M. Cox Josef D. Wolf Sabine Santibanez Annette Mankertz Roland Plesker Zachary M. Sticher Alexander A. Kolkykhalov Michael G. Natchus Christian K. Pfaller Richard K. Plemper Veronika von Messling Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
description	Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.
format	article
author	Kevin Wittwer Danielle E. Anderson Kristin Pfeffermann Robert M. Cox Josef D. Wolf Sabine Santibanez Annette Mankertz Roland Plesker Zachary M. Sticher Alexander A. Kolkykhalov Michael G. Natchus Christian K. Pfaller Richard K. Plemper Veronika von Messling
author_facet	Kevin Wittwer Danielle E. Anderson Kristin Pfeffermann Robert M. Cox Josef D. Wolf Sabine Santibanez Annette Mankertz Roland Plesker Zachary M. Sticher Alexander A. Kolkykhalov Michael G. Natchus Christian K. Pfaller Richard K. Plemper Veronika von Messling
author_sort	Kevin Wittwer
title	Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
title_short	Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
title_full	Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
title_fullStr	Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
title_full_unstemmed	Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
title_sort	small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5330f59bd9fe43ada6a0147032c636eb
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Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

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