Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis

Multiciliogenesis requires activation of transcriptional and protein assembly programs; however, the mechanisms that initiate the formation of these multiprotein complexes are unclear. Here the authors show that after inducing centriole biogenesis genes, the transcription factor E2f4 is required in...

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Autores principales:	Munemasa Mori, Renin Hazan, Paul S. Danielian, John E. Mahoney, Huijun Li, Jining Lu, Emily S. Miller, Xueliang Zhu, Jacqueline A. Lees, Wellington V. Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53330821599a435b8f2860c460f4ae1f
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spelling	oai:doaj.org-article:53330821599a435b8f2860c460f4ae1f2021-12-02T14:40:48ZCytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis10.1038/ncomms158572041-1723https://doaj.org/article/53330821599a435b8f2860c460f4ae1f2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15857https://doaj.org/toc/2041-1723Multiciliogenesis requires activation of transcriptional and protein assembly programs; however, the mechanisms that initiate the formation of these multiprotein complexes are unclear. Here the authors show that after inducing centriole biogenesis genes, the transcription factor E2f4 is required in the cytoplasm for assembly and nucleation of deuterosomes.Munemasa MoriRenin HazanPaul S. DanielianJohn E. MahoneyHuijun LiJining LuEmily S. MillerXueliang ZhuJacqueline A. LeesWellington V. CardosoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Munemasa Mori Renin Hazan Paul S. Danielian John E. Mahoney Huijun Li Jining Lu Emily S. Miller Xueliang Zhu Jacqueline A. Lees Wellington V. Cardoso Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
description	Multiciliogenesis requires activation of transcriptional and protein assembly programs; however, the mechanisms that initiate the formation of these multiprotein complexes are unclear. Here the authors show that after inducing centriole biogenesis genes, the transcription factor E2f4 is required in the cytoplasm for assembly and nucleation of deuterosomes.
format	article
author	Munemasa Mori Renin Hazan Paul S. Danielian John E. Mahoney Huijun Li Jining Lu Emily S. Miller Xueliang Zhu Jacqueline A. Lees Wellington V. Cardoso
author_facet	Munemasa Mori Renin Hazan Paul S. Danielian John E. Mahoney Huijun Li Jining Lu Emily S. Miller Xueliang Zhu Jacqueline A. Lees Wellington V. Cardoso
author_sort	Munemasa Mori
title	Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
title_short	Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
title_full	Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
title_fullStr	Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
title_full_unstemmed	Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
title_sort	cytoplasmic e2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53330821599a435b8f2860c460f4ae1f
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Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis

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