Lysine residue at position 22 of the AID protein regulates its class switch activity.

Lysine residue at position 22 of the AID protein regulates its class switch activity.

<h4>Background</h4>Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have...

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Autores principales: Roland Geisberger, Michael Huemer, Franz J Gassner, Nadja Zaborsky, Alexander Egle, Richard Greil
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/533339129a9440998e388d3f4e33ace4
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