Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

Abstract Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched hea...

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Autores principales:	Hana Štorkánová, Sabína Oreská, Maja Špiritović, Barbora Heřmánková, Kristýna Bubová, Martin Komarc, Karel Pavelka, Jiří Vencovský, Jörg H. W. Distler, Ladislav Šenolt, Radim Bečvář, Michal Tomčík
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5335953ded3743c185f7037d8a1d509a
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spelling	oai:doaj.org-article:5335953ded3743c185f7037d8a1d509a2021-12-02T15:08:22ZPlasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study10.1038/s41598-020-79139-82045-2322https://doaj.org/article/5335953ded3743c185f7037d8a1d509a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79139-8https://doaj.org/toc/2045-2322Abstract Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.Hana ŠtorkánováSabína OreskáMaja ŠpiritovićBarbora HeřmánkováKristýna BubováMartin KomarcKarel PavelkaJiří VencovskýJörg H. W. DistlerLadislav ŠenoltRadim BečvářMichal TomčíkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hana Štorkánová Sabína Oreská Maja Špiritović Barbora Heřmánková Kristýna Bubová Martin Komarc Karel Pavelka Jiří Vencovský Jörg H. W. Distler Ladislav Šenolt Radim Bečvář Michal Tomčík Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
description	Abstract Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.
format	article
author	Hana Štorkánová Sabína Oreská Maja Špiritović Barbora Heřmánková Kristýna Bubová Martin Komarc Karel Pavelka Jiří Vencovský Jörg H. W. Distler Ladislav Šenolt Radim Bečvář Michal Tomčík
author_facet	Hana Štorkánová Sabína Oreská Maja Špiritović Barbora Heřmánková Kristýna Bubová Martin Komarc Karel Pavelka Jiří Vencovský Jörg H. W. Distler Ladislav Šenolt Radim Bečvář Michal Tomčík
author_sort	Hana Štorkánová
title	Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
title_short	Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
title_full	Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
title_fullStr	Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
title_full_unstemmed	Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
title_sort	plasma hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5335953ded3743c185f7037d8a1d509a
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Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

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