Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes

Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA and identify potential therapeutic targets.

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Autores principales:	Rizi Ai, Teresina Laragione, Deepa Hammaker, David L. Boyle, Andre Wildberg, Keisuke Maeshima, Emanuele Palescandolo, Vinod Krishna, David Pocalyko, John W. Whitaker, Yuchen Bai, Sunil Nagpal, Kurtis E. Bachman, Richard I. Ainsworth, Mengchi Wang, Bo Ding, Percio S. Gulko, Wei Wang, Gary S. Firestein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5335c5581683468bbfffd411af6416a5
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spelling	oai:doaj.org-article:5335c5581683468bbfffd411af6416a52021-12-02T16:49:48ZComprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes10.1038/s41467-018-04310-92041-1723https://doaj.org/article/5335c5581683468bbfffd411af6416a52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04310-9https://doaj.org/toc/2041-1723Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA and identify potential therapeutic targets.Rizi AiTeresina LaragioneDeepa HammakerDavid L. BoyleAndre WildbergKeisuke MaeshimaEmanuele PalescandoloVinod KrishnaDavid PocalykoJohn W. WhitakerYuchen BaiSunil NagpalKurtis E. BachmanRichard I. AinsworthMengchi WangBo DingPercio S. GulkoWei WangGary S. FiresteinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rizi Ai Teresina Laragione Deepa Hammaker David L. Boyle Andre Wildberg Keisuke Maeshima Emanuele Palescandolo Vinod Krishna David Pocalyko John W. Whitaker Yuchen Bai Sunil Nagpal Kurtis E. Bachman Richard I. Ainsworth Mengchi Wang Bo Ding Percio S. Gulko Wei Wang Gary S. Firestein Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
description	Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA and identify potential therapeutic targets.
format	article
author	Rizi Ai Teresina Laragione Deepa Hammaker David L. Boyle Andre Wildberg Keisuke Maeshima Emanuele Palescandolo Vinod Krishna David Pocalyko John W. Whitaker Yuchen Bai Sunil Nagpal Kurtis E. Bachman Richard I. Ainsworth Mengchi Wang Bo Ding Percio S. Gulko Wei Wang Gary S. Firestein
author_facet	Rizi Ai Teresina Laragione Deepa Hammaker David L. Boyle Andre Wildberg Keisuke Maeshima Emanuele Palescandolo Vinod Krishna David Pocalyko John W. Whitaker Yuchen Bai Sunil Nagpal Kurtis E. Bachman Richard I. Ainsworth Mengchi Wang Bo Ding Percio S. Gulko Wei Wang Gary S. Firestein
author_sort	Rizi Ai
title	Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
title_short	Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
title_full	Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
title_fullStr	Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
title_full_unstemmed	Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
title_sort	comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5335c5581683468bbfffd411af6416a5
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Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes

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