VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

Serum vascular endothelial growth factor (VEGF) is involved in follicular vascularization, oxygenation, and consequently in oocyte maturation and embryo development. Unanswered questions remain regarding the relationship of intrafollicular VEGF level in preovulatory leading follicles to oocyte matur...

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Autores principales:	Wen-Bin Wu, Hsuan-Ting Chen, Jun-Jie Lin, Tsung-Hsuan Lai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	angiogenesis folliculogenesis IVF ovarian reserve oocyte maturation VEGF Medicine R
Acceso en línea:	https://doaj.org/article/533b525bf2c3443aa31e2e0b6b8acabb
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spelling	oai:doaj.org-article:533b525bf2c3443aa31e2e0b6b8acabb2021-11-11T17:39:29ZVEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle10.3390/jcm102150322077-0383https://doaj.org/article/533b525bf2c3443aa31e2e0b6b8acabb2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5032https://doaj.org/toc/2077-0383Serum vascular endothelial growth factor (VEGF) is involved in follicular vascularization, oxygenation, and consequently in oocyte maturation and embryo development. Unanswered questions remain regarding the relationship of intrafollicular VEGF level in preovulatory leading follicles to oocyte maturation and ovarian reserve during ovarian stimulation. We conducted this study to investigate the relationship of intrafollicular VEGF level in the fluid of single preovulatory leading follicles to ovarian reserve and oocyte maturation in patients receiving GnRH antagonist in vitro fertilization (IVF) protocol treatment. One hundred and eighty-five patients receiving IVF treatment were recruited and assigned to low-, normal-, and high-ovarian-reserve groups according to their serum anti-Müllerian hormone (AMH) level. Follicular fluid (FF) in preovulatory leading follicles, serum profiles, and clinical variables were collected for analysis. The result disclosed a significant among-group difference in FF VEGF concentration. Moreover, the serum AMH level was also negatively correlated with FF VEGF level. The oocyte maturation rate tended to be increased at higher AMH levels. FF VEGF concentration was significantly positively correlated with basal FSH level. In conclusion, FF VEGF concentration has a negative association with ovarian reserve level and oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols.Wen-Bin WuHsuan-Ting ChenJun-Jie LinTsung-Hsuan LaiMDPI AGarticleangiogenesisfolliculogenesisIVFovarian reserveoocyte maturationVEGFMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5032, p 5032 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiogenesis folliculogenesis IVF ovarian reserve oocyte maturation VEGF Medicine R
spellingShingle	angiogenesis folliculogenesis IVF ovarian reserve oocyte maturation VEGF Medicine R Wen-Bin Wu Hsuan-Ting Chen Jun-Jie Lin Tsung-Hsuan Lai VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle
description	Serum vascular endothelial growth factor (VEGF) is involved in follicular vascularization, oxygenation, and consequently in oocyte maturation and embryo development. Unanswered questions remain regarding the relationship of intrafollicular VEGF level in preovulatory leading follicles to oocyte maturation and ovarian reserve during ovarian stimulation. We conducted this study to investigate the relationship of intrafollicular VEGF level in the fluid of single preovulatory leading follicles to ovarian reserve and oocyte maturation in patients receiving GnRH antagonist in vitro fertilization (IVF) protocol treatment. One hundred and eighty-five patients receiving IVF treatment were recruited and assigned to low-, normal-, and high-ovarian-reserve groups according to their serum anti-Müllerian hormone (AMH) level. Follicular fluid (FF) in preovulatory leading follicles, serum profiles, and clinical variables were collected for analysis. The result disclosed a significant among-group difference in FF VEGF concentration. Moreover, the serum AMH level was also negatively correlated with FF VEGF level. The oocyte maturation rate tended to be increased at higher AMH levels. FF VEGF concentration was significantly positively correlated with basal FSH level. In conclusion, FF VEGF concentration has a negative association with ovarian reserve level and oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols.
format	article
author	Wen-Bin Wu Hsuan-Ting Chen Jun-Jie Lin Tsung-Hsuan Lai
author_facet	Wen-Bin Wu Hsuan-Ting Chen Jun-Jie Lin Tsung-Hsuan Lai
author_sort	Wen-Bin Wu
title	VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle
title_short	VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle
title_full	VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle
title_fullStr	VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle
title_full_unstemmed	VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle
title_sort	vegf concentration in a preovulatory leading follicle relates to ovarian reserve and oocyte maturation during ovarian stimulation with gnrh antagonist protocol in in vitro fertilization cycle
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/533b525bf2c3443aa31e2e0b6b8acabb
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_version_	1718432000973471744

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

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