Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry

Abstract The aim of this study was to provide definitive reference values for bone mineral density (BMD) and bone turnover markers in the general elderly population. Registered citizens of 50 to 89 years old were targeted for this survey. After random sampling from the resident registry of Obuse tow...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ryosuke Tokida, Masashi Uehara, Masaki Nakano, Takako Suzuki, Noriko Sakai, Shota Ikegami, Jun Takahashi, Yukio Nakamura, Hiroyuki Kato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/533d6f2bf20f4792ae7eb12d64e8141f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:533d6f2bf20f4792ae7eb12d64e8141f
record_format	dspace
spelling	oai:doaj.org-article:533d6f2bf20f4792ae7eb12d64e8141f2021-12-02T14:26:57ZReference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry10.1038/s41598-021-87393-72045-2322https://doaj.org/article/533d6f2bf20f4792ae7eb12d64e8141f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87393-7https://doaj.org/toc/2045-2322Abstract The aim of this study was to provide definitive reference values for bone mineral density (BMD) and bone turnover markers in the general elderly population. Registered citizens of 50 to 89 years old were targeted for this survey. After random sampling from the resident registry of Obuse town, we established eight groups based on age (50 s, 60 s, 70 s, and 80 s) and gender. A total of 411 people were enrolled. We used a dual-energy x-ray absorptiometry device to measure and evaluate BMD. The bone formation marker bone alkaline phosphatase (BAP) was measured as a bone turnover marker. Bone quality marker pentosidine, and bone resorption markers including urinary total deoxypyridinoline (DPD), tartrate-resistant acid phosphatase 5b (TRACP-5b), 25-hydroxyvitamin D (25[OH]D), and whole parathyroid hormone (PTH) were also measured as bone turnover markers. Sixty-three people (15.3%) were diagnosed as osteoporosis. BMD decreased with age in the femoral neck and total hip. On the other hand, there was no characteristic change with age in the lumber spine. As for bone markers, pentosidine and DPD increased with aging, although 25(OH)D, whole PTH, and BAP showed no characteristic associations with gender and aging. In terms of the relationship between low BMD and bone markers, there was a significant independent association between low BMD and TRACP-5b in females. In conclusions, hip BMD decreased with aging in men and women. However, there was no characteristic decline with aging in the lumbar spine. All bone markers showed no significant independent characteristics associated with age or gender in a multivariate analysis model, except for a significant association between low BMD and TRACP-5b in females. TRACP-5b was a potentially useful marker for the detection of low BMD.Ryosuke TokidaMasashi UeharaMasaki NakanoTakako SuzukiNoriko SakaiShota IkegamiJun TakahashiYukio NakamuraHiroyuki KatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryosuke Tokida Masashi Uehara Masaki Nakano Takako Suzuki Noriko Sakai Shota Ikegami Jun Takahashi Yukio Nakamura Hiroyuki Kato Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry
description	Abstract The aim of this study was to provide definitive reference values for bone mineral density (BMD) and bone turnover markers in the general elderly population. Registered citizens of 50 to 89 years old were targeted for this survey. After random sampling from the resident registry of Obuse town, we established eight groups based on age (50 s, 60 s, 70 s, and 80 s) and gender. A total of 411 people were enrolled. We used a dual-energy x-ray absorptiometry device to measure and evaluate BMD. The bone formation marker bone alkaline phosphatase (BAP) was measured as a bone turnover marker. Bone quality marker pentosidine, and bone resorption markers including urinary total deoxypyridinoline (DPD), tartrate-resistant acid phosphatase 5b (TRACP-5b), 25-hydroxyvitamin D (25[OH]D), and whole parathyroid hormone (PTH) were also measured as bone turnover markers. Sixty-three people (15.3%) were diagnosed as osteoporosis. BMD decreased with age in the femoral neck and total hip. On the other hand, there was no characteristic change with age in the lumber spine. As for bone markers, pentosidine and DPD increased with aging, although 25(OH)D, whole PTH, and BAP showed no characteristic associations with gender and aging. In terms of the relationship between low BMD and bone markers, there was a significant independent association between low BMD and TRACP-5b in females. In conclusions, hip BMD decreased with aging in men and women. However, there was no characteristic decline with aging in the lumbar spine. All bone markers showed no significant independent characteristics associated with age or gender in a multivariate analysis model, except for a significant association between low BMD and TRACP-5b in females. TRACP-5b was a potentially useful marker for the detection of low BMD.
format	article
author	Ryosuke Tokida Masashi Uehara Masaki Nakano Takako Suzuki Noriko Sakai Shota Ikegami Jun Takahashi Yukio Nakamura Hiroyuki Kato
author_facet	Ryosuke Tokida Masashi Uehara Masaki Nakano Takako Suzuki Noriko Sakai Shota Ikegami Jun Takahashi Yukio Nakamura Hiroyuki Kato
author_sort	Ryosuke Tokida
title	Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry
title_short	Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry
title_full	Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry
title_fullStr	Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry
title_full_unstemmed	Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry
title_sort	reference values for bone metabolism in a japanese cohort survey randomly sampled from a basic elderly resident registry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/533d6f2bf20f4792ae7eb12d64e8141f
work_keys_str_mv	AT ryosuketokida referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT masashiuehara referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT masakinakano referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT takakosuzuki referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT norikosakai referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT shotaikegami referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT juntakahashi referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT yukionakamura referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry AT hiroyukikato referencevaluesforbonemetabolisminajapanesecohortsurveyrandomlysampledfromabasicelderlyresidentregistry
_version_	1718391308662341632

Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry

Ejemplares similares