Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

Epithelia are exposed to diverse types of environmental stress, but the mechanisms by which epithelial cells sense stress are not well understood. Here, the authors show that a Nox-ROS-Ask1-MKK3-p38 signaling axis integrates various types of stress to promote intestinal regeneration.

Guardado en:

Detalles Bibliográficos
Autores principales:	Parthive H. Patel, Clothilde Pénalva, Michael Kardorff, Marianne Roca, Bojana Pavlović, Anja Thiel, Aurelio A. Teleman, Bruce A. Edgar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53418b588147421790d9a80c1509a940
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53418b588147421790d9a80c1509a940
record_format	dspace
spelling	oai:doaj.org-article:53418b588147421790d9a80c1509a9402021-12-02T14:38:39ZDamage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut10.1038/s41467-019-12336-w2041-1723https://doaj.org/article/53418b588147421790d9a80c1509a9402019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12336-whttps://doaj.org/toc/2041-1723Epithelia are exposed to diverse types of environmental stress, but the mechanisms by which epithelial cells sense stress are not well understood. Here, the authors show that a Nox-ROS-Ask1-MKK3-p38 signaling axis integrates various types of stress to promote intestinal regeneration.Parthive H. PatelClothilde PénalvaMichael KardorffMarianne RocaBojana PavlovićAnja ThielAurelio A. TelemanBruce A. EdgarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Parthive H. Patel Clothilde Pénalva Michael Kardorff Marianne Roca Bojana Pavlović Anja Thiel Aurelio A. Teleman Bruce A. Edgar Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
description	Epithelia are exposed to diverse types of environmental stress, but the mechanisms by which epithelial cells sense stress are not well understood. Here, the authors show that a Nox-ROS-Ask1-MKK3-p38 signaling axis integrates various types of stress to promote intestinal regeneration.
format	article
author	Parthive H. Patel Clothilde Pénalva Michael Kardorff Marianne Roca Bojana Pavlović Anja Thiel Aurelio A. Teleman Bruce A. Edgar
author_facet	Parthive H. Patel Clothilde Pénalva Michael Kardorff Marianne Roca Bojana Pavlović Anja Thiel Aurelio A. Teleman Bruce A. Edgar
author_sort	Parthive H. Patel
title	Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
title_short	Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
title_full	Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
title_fullStr	Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
title_full_unstemmed	Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
title_sort	damage sensing by a nox-ask1-mkk3-p38 signaling pathway mediates regeneration in the adult drosophila midgut
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/53418b588147421790d9a80c1509a940
work_keys_str_mv	AT parthivehpatel damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT clothildepenalva damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT michaelkardorff damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT marianneroca damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT bojanapavlovic damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT anjathiel damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT aurelioateleman damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut AT bruceaedgar damagesensingbyanoxask1mkk3p38signalingpathwaymediatesregenerationintheadultdrosophilamidgut
_version_	1718390893668466688

Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

Ejemplares similares