Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and prot...

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Autores principales:	Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley, Drew Weissman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5342eb93bec04c388435188e0f3081ae
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spelling	oai:doaj.org-article:5342eb93bec04c388435188e0f3081ae2021-12-02T16:56:54ZNucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies10.1038/s41467-018-05482-02041-1723https://doaj.org/article/5342eb93bec04c388435188e0f3081ae2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05482-0https://doaj.org/toc/2041-1723The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and protects from heterosubtypic virus infection.Norbert PardiKaela ParkhouseEricka KirkpatrickMeagan McMahonSeth J. ZostBarbara L. MuiYing K. TamKatalin KarikóChristopher J. BarbosaThomas D. MaddenMichael J. HopeFlorian KrammerScott E. HensleyDrew WeissmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Norbert Pardi Kaela Parkhouse Ericka Kirkpatrick Meagan McMahon Seth J. Zost Barbara L. Mui Ying K. Tam Katalin Karikó Christopher J. Barbosa Thomas D. Madden Michael J. Hope Florian Krammer Scott E. Hensley Drew Weissman Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
description	The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and protects from heterosubtypic virus infection.
format	article
author	Norbert Pardi Kaela Parkhouse Ericka Kirkpatrick Meagan McMahon Seth J. Zost Barbara L. Mui Ying K. Tam Katalin Karikó Christopher J. Barbosa Thomas D. Madden Michael J. Hope Florian Krammer Scott E. Hensley Drew Weissman
author_facet	Norbert Pardi Kaela Parkhouse Ericka Kirkpatrick Meagan McMahon Seth J. Zost Barbara L. Mui Ying K. Tam Katalin Karikó Christopher J. Barbosa Thomas D. Madden Michael J. Hope Florian Krammer Scott E. Hensley Drew Weissman
author_sort	Norbert Pardi
title	Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
title_short	Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
title_full	Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
title_fullStr	Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
title_full_unstemmed	Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
title_sort	nucleoside-modified mrna immunization elicits influenza virus hemagglutinin stalk-specific antibodies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5342eb93bec04c388435188e0f3081ae
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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

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