Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma

Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/−tumour B cells through the CD95L/CD95 axis, leading to the production of IL-10 and suppressi...

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Autores principales:	Fang-Zhu Ouyang, Rui-Qi Wu, Yuan Wei, Rui-Xian Liu, Dong Yang, Xiao Xiao, Limin Zheng, Bo Li, Xiang-Ming Lao, Dong-Ming Kuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/534343b5bfdd47d7a44baf086ba66fd1
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spelling	oai:doaj.org-article:534343b5bfdd47d7a44baf086ba66fd12021-12-02T14:39:29ZDendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma10.1038/ncomms134532041-1723https://doaj.org/article/534343b5bfdd47d7a44baf086ba66fd12016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13453https://doaj.org/toc/2041-1723Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/−tumour B cells through the CD95L/CD95 axis, leading to the production of IL-10 and suppression of CD8 T cells.Fang-Zhu OuyangRui-Qi WuYuan WeiRui-Xian LiuDong YangXiao XiaoLimin ZhengBo LiXiang-Ming LaoDong-Ming KuangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fang-Zhu Ouyang Rui-Qi Wu Yuan Wei Rui-Xian Liu Dong Yang Xiao Xiao Limin Zheng Bo Li Xiang-Ming Lao Dong-Ming Kuang Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma
description	Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/−tumour B cells through the CD95L/CD95 axis, leading to the production of IL-10 and suppression of CD8 T cells.
format	article
author	Fang-Zhu Ouyang Rui-Qi Wu Yuan Wei Rui-Xian Liu Dong Yang Xiao Xiao Limin Zheng Bo Li Xiang-Ming Lao Dong-Ming Kuang
author_facet	Fang-Zhu Ouyang Rui-Qi Wu Yuan Wei Rui-Xian Liu Dong Yang Xiao Xiao Limin Zheng Bo Li Xiang-Ming Lao Dong-Ming Kuang
author_sort	Fang-Zhu Ouyang
title	Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma
title_short	Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma
title_full	Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma
title_fullStr	Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma
title_full_unstemmed	Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma
title_sort	dendritic cell-elicited b-cell activation fosters immune privilege via il-10 signals in hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/534343b5bfdd47d7a44baf086ba66fd1
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Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma

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