A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

Microviridins belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, the authors discover a microviridin-synthesizing enzyme in a cyanobacterium that modifies multiple core peptides from a single substrate in a distributive and unstrictly directiona...

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Main Authors:	Yi Zhang, Kunhua Li, Guang Yang, Joshua L. McBride, Steven D. Bruner, Yousong Ding
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/53446e23a9ff4d789b35b5ea2e0b7e03
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id	oai:doaj.org-article:53446e23a9ff4d789b35b5ea2e0b7e03
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spelling	oai:doaj.org-article:53446e23a9ff4d789b35b5ea2e0b7e032021-12-02T14:41:06ZA distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate10.1038/s41467-018-04154-32041-1723https://doaj.org/article/53446e23a9ff4d789b35b5ea2e0b7e032018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04154-3https://doaj.org/toc/2041-1723Microviridins belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, the authors discover a microviridin-synthesizing enzyme in a cyanobacterium that modifies multiple core peptides from a single substrate in a distributive and unstrictly directional manner, an unusual biosynthetic logic for RiPPs.Yi ZhangKunhua LiGuang YangJoshua L. McBrideSteven D. BrunerYousong DingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Zhang Kunhua Li Guang Yang Joshua L. McBride Steven D. Bruner Yousong Ding A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
description	Microviridins belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, the authors discover a microviridin-synthesizing enzyme in a cyanobacterium that modifies multiple core peptides from a single substrate in a distributive and unstrictly directional manner, an unusual biosynthetic logic for RiPPs.
format	article
author	Yi Zhang Kunhua Li Guang Yang Joshua L. McBride Steven D. Bruner Yousong Ding
author_facet	Yi Zhang Kunhua Li Guang Yang Joshua L. McBride Steven D. Bruner Yousong Ding
author_sort	Yi Zhang
title	A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
title_short	A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
title_full	A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
title_fullStr	A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
title_full_unstemmed	A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
title_sort	distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/53446e23a9ff4d789b35b5ea2e0b7e03
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A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

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