Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study

Objectives: Understand the long-term mortality, risk of readmission for sepsis and cause of death following a gram-negative bloodstream infection (GN-BSI). Methods: This was a propensity-matched study using data linkage of Queensland hospital data, Australia. GN-BSIs were collected from 2005 to 2010...

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Autores principales:	John F. McNamara, Patrick N.A. Harris, Mark D. Chatfield, David L. Paterson
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	sepsis bloodstream infection mortality gram negative cause of death Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5346ca7e26ca40abb10db39ac9a1c751
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spelling	oai:doaj.org-article:5346ca7e26ca40abb10db39ac9a1c7512021-11-24T04:27:17ZLong term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study1201-971210.1016/j.ijid.2021.10.047https://doaj.org/article/5346ca7e26ca40abb10db39ac9a1c7512022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008304https://doaj.org/toc/1201-9712Objectives: Understand the long-term mortality, risk of readmission for sepsis and cause of death following a gram-negative bloodstream infection (GN-BSI). Methods: This was a propensity-matched study using data linkage of Queensland hospital data, Australia. GN-BSIs were collected from 2005 to 2010 and matched 1:1 to hospital admissions without BSI for age, gender, year of culture collection, frequency of admissions in the prior year and Charlson-Deyo Comorbidity score and each comorbidity within the Charlson-Deyo score. Readmissions for sepsis, mortality and causes of death were evaluated. Results: Cases of GN-BSI were propensity-matched 1:1 to culture-negative hospital admissions (n = 14016). Readmissions for sepsis were higher in the GN-BSI cohort from 91 to 365 days (P < 0.001) and in the four subsequent years (P < 0.001). The five-year survival in the GN-BSI cohort was 52% versus 65% in the culture-negative cases (P < 0.001). Infection was only a common underlying cause of death within the first 90 days. Sepsis was the most common contributing cause of death (CCOD) for the two years following index culture in the GN-BSI cohort. Conclusions: Compared to a similarly vulnerable group of hospital attendees, GN-BSI had higher mortality and demonstrated a persistent long-term risk of readmission for sepsis and sepsis as a CCOD.John F. McNamaraPatrick N.A. HarrisMark D. ChatfieldDavid L. PatersonElsevierarticlesepsisbloodstream infectionmortalitygram negativecause of deathInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 114, Iss , Pp 34-44 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	sepsis bloodstream infection mortality gram negative cause of death Infectious and parasitic diseases RC109-216
spellingShingle	sepsis bloodstream infection mortality gram negative cause of death Infectious and parasitic diseases RC109-216 John F. McNamara Patrick N.A. Harris Mark D. Chatfield David L. Paterson Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
description	Objectives: Understand the long-term mortality, risk of readmission for sepsis and cause of death following a gram-negative bloodstream infection (GN-BSI). Methods: This was a propensity-matched study using data linkage of Queensland hospital data, Australia. GN-BSIs were collected from 2005 to 2010 and matched 1:1 to hospital admissions without BSI for age, gender, year of culture collection, frequency of admissions in the prior year and Charlson-Deyo Comorbidity score and each comorbidity within the Charlson-Deyo score. Readmissions for sepsis, mortality and causes of death were evaluated. Results: Cases of GN-BSI were propensity-matched 1:1 to culture-negative hospital admissions (n = 14016). Readmissions for sepsis were higher in the GN-BSI cohort from 91 to 365 days (P < 0.001) and in the four subsequent years (P < 0.001). The five-year survival in the GN-BSI cohort was 52% versus 65% in the culture-negative cases (P < 0.001). Infection was only a common underlying cause of death within the first 90 days. Sepsis was the most common contributing cause of death (CCOD) for the two years following index culture in the GN-BSI cohort. Conclusions: Compared to a similarly vulnerable group of hospital attendees, GN-BSI had higher mortality and demonstrated a persistent long-term risk of readmission for sepsis and sepsis as a CCOD.
format	article
author	John F. McNamara Patrick N.A. Harris Mark D. Chatfield David L. Paterson
author_facet	John F. McNamara Patrick N.A. Harris Mark D. Chatfield David L. Paterson
author_sort	John F. McNamara
title	Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
title_short	Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
title_full	Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
title_fullStr	Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
title_full_unstemmed	Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
title_sort	long term sepsis readmission, mortality and cause of death following gram negative bloodstream infection: a propensity matched observational linkage study
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/5346ca7e26ca40abb10db39ac9a1c751
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Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study

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