Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment

Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment

While neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs can directly interact with infiltrating T cells to promote an immunosuppressive TME. He...

Full description

Saved in:
Bibliographic Details
Main Authors: Christof Kaltenmeier, Hamza O. Yazdani, Kristin Morder, David A. Geller, Richard L. Simmons, Samer Tohme
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
neutrophil extracellular traps
tumor microenvironment
T cell exhaustion
T cell dysfunction
program death-ligand 1
PD-L1
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/5348aaf05b064dc9b2d68480273e0038
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/5348aaf05b064dc9b2d68480273e0038

Similar Items