Genetic variation affects binge feeding behavior in female inbred mouse strains

Abstract Identifying genetic variants that regulate binge eating (BE) is critical for understanding the factors that control this behavior and for the development of pharmacological treatment strategies. Although several studies have revealed specific genes capable of affecting BE behavior, less is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brandon A. Newmyer, Ciarra M. Whindleton, Nandan Srinivasa, Marieke K. Jones, Michael M. Scott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/534a0d6878134767a6fea52dfc38c183
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:534a0d6878134767a6fea52dfc38c183
record_format	dspace
spelling	oai:doaj.org-article:534a0d6878134767a6fea52dfc38c1832021-12-02T15:10:05ZGenetic variation affects binge feeding behavior in female inbred mouse strains10.1038/s41598-019-51874-72045-2322https://doaj.org/article/534a0d6878134767a6fea52dfc38c1832019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51874-7https://doaj.org/toc/2045-2322Abstract Identifying genetic variants that regulate binge eating (BE) is critical for understanding the factors that control this behavior and for the development of pharmacological treatment strategies. Although several studies have revealed specific genes capable of affecting BE behavior, less is known about how genetic variation modulates BE. Thus, through a paradigm that promoted binge-like food intake through intermittent access to high calorie diet (HCD), we quantified food-intake in four inbred mouse strains: C57Bl/6J (B6), NOD/LtJ (NOD), 129S1/SvlmJ (S1), and A/J (AJ). We report that genetic variation likely influences the chronic regulation of food intake and the binge-like consumption of a palatable HCD. AJ mice consumed more of both standard chow and HCD than the other three strains tested when both diets were available ad libitum, while S1 mice consumed significantly less HCD than other strains during intermittent HCD access. Behavioral differences were also associated with differential changes in c-Fos immunohistochemistry in brain regions traditionally associated with appetite regulation. Our results identify 129S1/SvlmJ as a strain that exhibits low levels of binge feeding behavior and suggests that this strain could be useful in the investigation of the influence of genetic variation in the control of binge food intake.Brandon A. NewmyerCiarra M. WhindletonNandan SrinivasaMarieke K. JonesMichael M. ScottNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brandon A. Newmyer Ciarra M. Whindleton Nandan Srinivasa Marieke K. Jones Michael M. Scott Genetic variation affects binge feeding behavior in female inbred mouse strains
description	Abstract Identifying genetic variants that regulate binge eating (BE) is critical for understanding the factors that control this behavior and for the development of pharmacological treatment strategies. Although several studies have revealed specific genes capable of affecting BE behavior, less is known about how genetic variation modulates BE. Thus, through a paradigm that promoted binge-like food intake through intermittent access to high calorie diet (HCD), we quantified food-intake in four inbred mouse strains: C57Bl/6J (B6), NOD/LtJ (NOD), 129S1/SvlmJ (S1), and A/J (AJ). We report that genetic variation likely influences the chronic regulation of food intake and the binge-like consumption of a palatable HCD. AJ mice consumed more of both standard chow and HCD than the other three strains tested when both diets were available ad libitum, while S1 mice consumed significantly less HCD than other strains during intermittent HCD access. Behavioral differences were also associated with differential changes in c-Fos immunohistochemistry in brain regions traditionally associated with appetite regulation. Our results identify 129S1/SvlmJ as a strain that exhibits low levels of binge feeding behavior and suggests that this strain could be useful in the investigation of the influence of genetic variation in the control of binge food intake.
format	article
author	Brandon A. Newmyer Ciarra M. Whindleton Nandan Srinivasa Marieke K. Jones Michael M. Scott
author_facet	Brandon A. Newmyer Ciarra M. Whindleton Nandan Srinivasa Marieke K. Jones Michael M. Scott
author_sort	Brandon A. Newmyer
title	Genetic variation affects binge feeding behavior in female inbred mouse strains
title_short	Genetic variation affects binge feeding behavior in female inbred mouse strains
title_full	Genetic variation affects binge feeding behavior in female inbred mouse strains
title_fullStr	Genetic variation affects binge feeding behavior in female inbred mouse strains
title_full_unstemmed	Genetic variation affects binge feeding behavior in female inbred mouse strains
title_sort	genetic variation affects binge feeding behavior in female inbred mouse strains
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/534a0d6878134767a6fea52dfc38c183
work_keys_str_mv	AT brandonanewmyer geneticvariationaffectsbingefeedingbehaviorinfemaleinbredmousestrains AT ciarramwhindleton geneticvariationaffectsbingefeedingbehaviorinfemaleinbredmousestrains AT nandansrinivasa geneticvariationaffectsbingefeedingbehaviorinfemaleinbredmousestrains AT mariekekjones geneticvariationaffectsbingefeedingbehaviorinfemaleinbredmousestrains AT michaelmscott geneticvariationaffectsbingefeedingbehaviorinfemaleinbredmousestrains
_version_	1718387752005795840

Genetic variation affects binge feeding behavior in female inbred mouse strains

Ejemplares similares