Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage

An altered mitochondrial DNA copy number (mtDNAcn) at birth can be a marker of increased disease susceptibility later in life. Gestational exposure to acute stress, such as that derived from the earthquake experienced on 19 September 2017 in Mexico City, could be associated with changes in mtDNAcn a...

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Autores principales:	Jonatan A. Mendoza-Ortega, Enrique Reyes-Muñoz, Sonia Nava-Salazar, Sandra Rodríguez-Martínez, Sandra B. Parra-Hernández, Lourdes Schnaas, Blanca Vianey Suárez-Rico, Libni A. Torres-Olascoaga, Andrea A. Baccarelli, Rosalind J. Wright, Robert O. Wright, Guadalupe Estrada-Gutierrez, Marcela Tamayo-Ortiz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mtDNAcn prenatal DOHAD earthquake Medicine R
Acceso en línea:	https://doaj.org/article/534a4a9a0fb34396be05a1368f6bf89c
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spelling	oai:doaj.org-article:534a4a9a0fb34396be05a1368f6bf89c2021-11-25T17:48:13ZMitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage10.3390/ijerph1822117711660-46011661-7827https://doaj.org/article/534a4a9a0fb34396be05a1368f6bf89c2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11771https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601An altered mitochondrial DNA copy number (mtDNAcn) at birth can be a marker of increased disease susceptibility later in life. Gestational exposure to acute stress, such as that derived from the earthquake experienced on 19 September 2017 in Mexico City, could be associated with changes in mtDNAcn at birth. Our study used data from the OBESO (Biochemical and Epigenetic Origins of Overweight and Obesity) perinatal cohort in Mexico City. We compared the mtDNAcn in the umbilical cord blood of 22 infants born before the earthquake, 24 infants whose mothers were pregnant at the time of the earthquake (exposed), and 37 who were conceived after the earthquake (post-earthquake). We quantified mtDNAcn by quantitative real-time polymerase chain reaction normalized with a nuclear gene. We used a linear model adjusted by maternal age, body mass index, socioeconomic status, perceived stress, and pregnancy comorbidities. Compared to non-exposed newborns (mean ± SD mtDNAcn: 0.740 ± 0.161), exposed and post-earthquake newborns (mtDNAcn: 0.899 ± 0.156 and 0.995 ± 0.169, respectively) had increased mtDNAcn, <i>p</i> = 0.001. The findings of this study point at mtDNAcn as a potential biological marker of acute stress and suggest that experiencing an earthquake during pregnancy or before gestation can have programing effects in the unborn child. Long-term follow-up of newborns to women who experience stress prenatally, particularly that derived from a natural disaster, is warranted.Jonatan A. Mendoza-OrtegaEnrique Reyes-MuñozSonia Nava-SalazarSandra Rodríguez-MartínezSandra B. Parra-HernándezLourdes SchnaasBlanca Vianey Suárez-RicoLibni A. Torres-OlascoagaAndrea A. BaccarelliRosalind J. WrightRobert O. WrightGuadalupe Estrada-GutierrezMarcela Tamayo-OrtizMDPI AGarticlemtDNAcnprenatalDOHADearthquakeMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11771, p 11771 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mtDNAcn prenatal DOHAD earthquake Medicine R
spellingShingle	mtDNAcn prenatal DOHAD earthquake Medicine R Jonatan A. Mendoza-Ortega Enrique Reyes-Muñoz Sonia Nava-Salazar Sandra Rodríguez-Martínez Sandra B. Parra-Hernández Lourdes Schnaas Blanca Vianey Suárez-Rico Libni A. Torres-Olascoaga Andrea A. Baccarelli Rosalind J. Wright Robert O. Wright Guadalupe Estrada-Gutierrez Marcela Tamayo-Ortiz Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage
description	An altered mitochondrial DNA copy number (mtDNAcn) at birth can be a marker of increased disease susceptibility later in life. Gestational exposure to acute stress, such as that derived from the earthquake experienced on 19 September 2017 in Mexico City, could be associated with changes in mtDNAcn at birth. Our study used data from the OBESO (Biochemical and Epigenetic Origins of Overweight and Obesity) perinatal cohort in Mexico City. We compared the mtDNAcn in the umbilical cord blood of 22 infants born before the earthquake, 24 infants whose mothers were pregnant at the time of the earthquake (exposed), and 37 who were conceived after the earthquake (post-earthquake). We quantified mtDNAcn by quantitative real-time polymerase chain reaction normalized with a nuclear gene. We used a linear model adjusted by maternal age, body mass index, socioeconomic status, perceived stress, and pregnancy comorbidities. Compared to non-exposed newborns (mean ± SD mtDNAcn: 0.740 ± 0.161), exposed and post-earthquake newborns (mtDNAcn: 0.899 ± 0.156 and 0.995 ± 0.169, respectively) had increased mtDNAcn, <i>p</i> = 0.001. The findings of this study point at mtDNAcn as a potential biological marker of acute stress and suggest that experiencing an earthquake during pregnancy or before gestation can have programing effects in the unborn child. Long-term follow-up of newborns to women who experience stress prenatally, particularly that derived from a natural disaster, is warranted.
format	article
author	Jonatan A. Mendoza-Ortega Enrique Reyes-Muñoz Sonia Nava-Salazar Sandra Rodríguez-Martínez Sandra B. Parra-Hernández Lourdes Schnaas Blanca Vianey Suárez-Rico Libni A. Torres-Olascoaga Andrea A. Baccarelli Rosalind J. Wright Robert O. Wright Guadalupe Estrada-Gutierrez Marcela Tamayo-Ortiz
author_facet	Jonatan A. Mendoza-Ortega Enrique Reyes-Muñoz Sonia Nava-Salazar Sandra Rodríguez-Martínez Sandra B. Parra-Hernández Lourdes Schnaas Blanca Vianey Suárez-Rico Libni A. Torres-Olascoaga Andrea A. Baccarelli Rosalind J. Wright Robert O. Wright Guadalupe Estrada-Gutierrez Marcela Tamayo-Ortiz
author_sort	Jonatan A. Mendoza-Ortega
title	Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage
title_short	Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage
title_full	Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage
title_fullStr	Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage
title_full_unstemmed	Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage
title_sort	mitochondrial dna copy number adaptation as a biological response derived from an earthquake at intrauterine stage
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/534a4a9a0fb34396be05a1368f6bf89c
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Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage

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