Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea

Abstract Obstructive sleep apnoea (OSA) is associated with repetitive breathing obstructions during sleep. These episodes of hypoxia and associated arousals from sleep induce physiological stress and nocturnal over-activation of the sympathetic nervous system (SNS). One consequence of OSA is impairm...

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Autores principales:	Ridwan M. Alomri, Gerard A. Kennedy, Siraj Omar Wali, Faris Alhejaili, Stephen R. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5351269507d14167b200c7eb62603875
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spelling	oai:doaj.org-article:5351269507d14167b200c7eb626038752021-12-02T14:59:29ZAssociation between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea10.1038/s41598-021-91329-62045-2322https://doaj.org/article/5351269507d14167b200c7eb626038752021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91329-6https://doaj.org/toc/2045-2322Abstract Obstructive sleep apnoea (OSA) is associated with repetitive breathing obstructions during sleep. These episodes of hypoxia and associated arousals from sleep induce physiological stress and nocturnal over-activation of the sympathetic nervous system (SNS). One consequence of OSA is impairment in a range of cognitive domains. Previous research into cognitive impairment in OSA have focussed on intermittent hypoxia and disrupted sleep, but not nocturnal over-activation of the SNS. Therefore, we investigated whether nocturnal over-activity of the SNS was associated with cognitive impairments in OSA. The extent of nocturnal SNS activation was estimated from heart rate variability (HRV), pulse wave amplitude (PWA) and stress response biomarkers (cortisol and glucose levels). OSA severity was significantly associated with PWA indices and the HRV low frequency/ high frequency ratio (p < 0.05). Morning blood glucose levels were significantly associated with the duration of a blood oxygen saturation (SaO2) < 90% (p < 0.01). PWA and HRV were significantly associated with the time taken to perform a task involving visuospatial functioning (p < 0.05), but not with impairments in sustained attention, reaction time or autobiographical memory. These results suggest that the visuospatial dysfunction observed in people with OSA is associated with increased nocturnal activity of the SNS.Ridwan M. AlomriGerard A. KennedySiraj Omar WaliFaris AlhejailiStephen R. RobinsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ridwan M. Alomri Gerard A. Kennedy Siraj Omar Wali Faris Alhejaili Stephen R. Robinson Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
description	Abstract Obstructive sleep apnoea (OSA) is associated with repetitive breathing obstructions during sleep. These episodes of hypoxia and associated arousals from sleep induce physiological stress and nocturnal over-activation of the sympathetic nervous system (SNS). One consequence of OSA is impairment in a range of cognitive domains. Previous research into cognitive impairment in OSA have focussed on intermittent hypoxia and disrupted sleep, but not nocturnal over-activation of the SNS. Therefore, we investigated whether nocturnal over-activity of the SNS was associated with cognitive impairments in OSA. The extent of nocturnal SNS activation was estimated from heart rate variability (HRV), pulse wave amplitude (PWA) and stress response biomarkers (cortisol and glucose levels). OSA severity was significantly associated with PWA indices and the HRV low frequency/ high frequency ratio (p < 0.05). Morning blood glucose levels were significantly associated with the duration of a blood oxygen saturation (SaO2) < 90% (p < 0.01). PWA and HRV were significantly associated with the time taken to perform a task involving visuospatial functioning (p < 0.05), but not with impairments in sustained attention, reaction time or autobiographical memory. These results suggest that the visuospatial dysfunction observed in people with OSA is associated with increased nocturnal activity of the SNS.
format	article
author	Ridwan M. Alomri Gerard A. Kennedy Siraj Omar Wali Faris Alhejaili Stephen R. Robinson
author_facet	Ridwan M. Alomri Gerard A. Kennedy Siraj Omar Wali Faris Alhejaili Stephen R. Robinson
author_sort	Ridwan M. Alomri
title	Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
title_short	Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
title_full	Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
title_fullStr	Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
title_full_unstemmed	Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
title_sort	association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5351269507d14167b200c7eb62603875
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Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea

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