Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients

Background: Following the paucity of safety reports in the use of Artemisinin-Based Combination Therapies (ACTs) plus paracetamol, the study assessed safety potential of artemether-lumefantrine (ALP), artesunate-amodiaquine (AAP), artesunate-mefloquine (AMP), artesunate-sulphadoxine-pyrimethamine (A...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S.E. Aghahowa, R.I. Ozolua, E.E. Bafor, P. Obarisiagbon, A.O. Isah
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	ACTs Paracetamol Safety Malaria Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/5355ca03fc244872bc16b6fc0c67de47
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5355ca03fc244872bc16b6fc0c67de47
record_format	dspace
spelling	oai:doaj.org-article:5355ca03fc244872bc16b6fc0c67de472021-12-04T04:34:21ZToxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients2214-750010.1016/j.toxrep.2021.11.007https://doaj.org/article/5355ca03fc244872bc16b6fc0c67de472021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214750021001918https://doaj.org/toc/2214-7500Background: Following the paucity of safety reports in the use of Artemisinin-Based Combination Therapies (ACTs) plus paracetamol, the study assessed safety potential of artemether-lumefantrine (ALP), artesunate-amodiaquine (AAP), artesunate-mefloquine (AMP), artesunate-sulphadoxine-pyrimethamine (ASPP) and dihydroartemisinin-piperaquine (DHPP) combination with paracetamol in malaria patients. Methods: ACTs and paracetamol were administered concomitantly in conventional doses/regimen to randomly selected patients. Blood samples were collected from the ante-cubital vein before and after completion of therapies. Toxicity markers such as weights, glucose, lipids, renal electrolytes, liver enzymes and haematological indices were assessed using standard protocols. Results: The total numbers of participants were 57 patients. Male to female ratio was 1:1.1. Mean body weight and ages were 59.19 ± 1.39 kg and 42.86 ± 1.32 years respectively. The mean temperatures prior to and after therapy were 37.49 ± 1.02 °C and 37.50 ± 0.17 °C respectively. Mean parasitaemia before the commencement of therapy was 6282 ± 21.01 parasites/μl. Out of thirty-seven toxicological indices evaluated, twenty–four were significantly altered by ACTs plus paracetamol (P < 0.05). Increased serum toxicity markers due to the drug combinations were glucose (AAP, AMP), urea (ALP, ASPP), bicarbonate ion (ALP, AAP, AMP, ASPP), chloride ion (ALP, AAP, AMP), creatinine (ALP, AAP, AMP, ASPP), alkaline phosphatase (ALP, AAP), aspartate aminotransferase and alanine aminotransferase (ALP, AAP, AMP, ASPP, DHPP), total protein (AMP, DHPP) and albumin (AMP, DHPP). Decreased serum toxicity markers due to the drugs were glucose (ALP, ASPP, DHPP), urea (AMP), bicarbonate ion (DHPP), chloride ion (ASPP, DHPP), creatinine (DHPP), alkaline phosphatase (AMP, ASPP, DHPP), total protein (ALP, AAP, and ASPP) and albumin (ALP, AAP, ASPP). Altered haematological indices were white blood cells, red blood cells, mean cell haemoglobin and platelets. Conclusion: Since ACTs plus paracetamol altered human system, discrete selection is essential in managing uncomplicated malaria most especially in patients with co-morbid conditions.S.E. AghahowaR.I. OzoluaE.E. BaforP. ObarisiagbonA.O. IsahElsevierarticleACTsParacetamolSafetyMalariaToxicology. PoisonsRA1190-1270ENToxicology Reports, Vol 8, Iss , Pp 1930-1936 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ACTs Paracetamol Safety Malaria Toxicology. Poisons RA1190-1270
spellingShingle	ACTs Paracetamol Safety Malaria Toxicology. Poisons RA1190-1270 S.E. Aghahowa R.I. Ozolua E.E. Bafor P. Obarisiagbon A.O. Isah Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients
description	Background: Following the paucity of safety reports in the use of Artemisinin-Based Combination Therapies (ACTs) plus paracetamol, the study assessed safety potential of artemether-lumefantrine (ALP), artesunate-amodiaquine (AAP), artesunate-mefloquine (AMP), artesunate-sulphadoxine-pyrimethamine (ASPP) and dihydroartemisinin-piperaquine (DHPP) combination with paracetamol in malaria patients. Methods: ACTs and paracetamol were administered concomitantly in conventional doses/regimen to randomly selected patients. Blood samples were collected from the ante-cubital vein before and after completion of therapies. Toxicity markers such as weights, glucose, lipids, renal electrolytes, liver enzymes and haematological indices were assessed using standard protocols. Results: The total numbers of participants were 57 patients. Male to female ratio was 1:1.1. Mean body weight and ages were 59.19 ± 1.39 kg and 42.86 ± 1.32 years respectively. The mean temperatures prior to and after therapy were 37.49 ± 1.02 °C and 37.50 ± 0.17 °C respectively. Mean parasitaemia before the commencement of therapy was 6282 ± 21.01 parasites/μl. Out of thirty-seven toxicological indices evaluated, twenty–four were significantly altered by ACTs plus paracetamol (P < 0.05). Increased serum toxicity markers due to the drug combinations were glucose (AAP, AMP), urea (ALP, ASPP), bicarbonate ion (ALP, AAP, AMP, ASPP), chloride ion (ALP, AAP, AMP), creatinine (ALP, AAP, AMP, ASPP), alkaline phosphatase (ALP, AAP), aspartate aminotransferase and alanine aminotransferase (ALP, AAP, AMP, ASPP, DHPP), total protein (AMP, DHPP) and albumin (AMP, DHPP). Decreased serum toxicity markers due to the drugs were glucose (ALP, ASPP, DHPP), urea (AMP), bicarbonate ion (DHPP), chloride ion (ASPP, DHPP), creatinine (DHPP), alkaline phosphatase (AMP, ASPP, DHPP), total protein (ALP, AAP, and ASPP) and albumin (ALP, AAP, ASPP). Altered haematological indices were white blood cells, red blood cells, mean cell haemoglobin and platelets. Conclusion: Since ACTs plus paracetamol altered human system, discrete selection is essential in managing uncomplicated malaria most especially in patients with co-morbid conditions.
format	article
author	S.E. Aghahowa R.I. Ozolua E.E. Bafor P. Obarisiagbon A.O. Isah
author_facet	S.E. Aghahowa R.I. Ozolua E.E. Bafor P. Obarisiagbon A.O. Isah
author_sort	S.E. Aghahowa
title	Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients
title_short	Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients
title_full	Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients
title_fullStr	Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients
title_full_unstemmed	Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients
title_sort	toxicological effect of artemisinin-based combination therapies plus paracetamol in malaria patients
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5355ca03fc244872bc16b6fc0c67de47
work_keys_str_mv	AT seaghahowa toxicologicaleffectofartemisininbasedcombinationtherapiesplusparacetamolinmalariapatients AT riozolua toxicologicaleffectofartemisininbasedcombinationtherapiesplusparacetamolinmalariapatients AT eebafor toxicologicaleffectofartemisininbasedcombinationtherapiesplusparacetamolinmalariapatients AT pobarisiagbon toxicologicaleffectofartemisininbasedcombinationtherapiesplusparacetamolinmalariapatients AT aoisah toxicologicaleffectofartemisininbasedcombinationtherapiesplusparacetamolinmalariapatients
_version_	1718372966571442176

Toxicological effect of Artemisinin-Based Combination Therapies plus Paracetamol in malaria patients

Ejemplares similares