Specific contribution of neurons from the Dbx1 lineage to the piriform cortex

Abstract The piriform cortex (PC) is a major cortical processing center for the sense of smell that receives direct inputs from the olfactory bulb. In mice, the PC consists of three neuronal layers, which are populated by cells with distinct developmental origins. One origin of PC neurons is the poo...

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Autores principales:	Thando Shabangu, Hung-Lun Chen, Zi-hui Zhuang, Alessandra Pierani, Chien-Fu F. Chen, Shen-Ju Chou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5356334909ca4d4388dae6b6c4e8281f
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spelling	oai:doaj.org-article:5356334909ca4d4388dae6b6c4e8281f2021-12-02T18:03:31ZSpecific contribution of neurons from the Dbx1 lineage to the piriform cortex10.1038/s41598-021-86512-82045-2322https://doaj.org/article/5356334909ca4d4388dae6b6c4e8281f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86512-8https://doaj.org/toc/2045-2322Abstract The piriform cortex (PC) is a major cortical processing center for the sense of smell that receives direct inputs from the olfactory bulb. In mice, the PC consists of three neuronal layers, which are populated by cells with distinct developmental origins. One origin of PC neurons is the pool of Dbx1-expressing neural progenitors located in the ventral pallium at the pallial-subpallial boundary. Since the precise mechanisms of PC neuron development are largely unknown, we sought to define the distribution, timing of neurogenesis, morphology and projection patterns of PC neurons from the Dbx1 lineage. We found that Dbx1-lineage neurons are preferentially distributed in layer 2 and enriched in the ventral portion of the PC. Further, Dbx1 neurons are early-born neurons and contribute to most neuronal subtypes in the PC. Our data also revealed an enrichment of Dbx1-lineage neurons in the ventral anterior PC that project to the orbitofrontal cortex. These findings suggest a specific association between the developmental origin of PC neurons and their neuronal properties.Thando ShabanguHung-Lun ChenZi-hui ZhuangAlessandra PieraniChien-Fu F. ChenShen-Ju ChouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thando Shabangu Hung-Lun Chen Zi-hui Zhuang Alessandra Pierani Chien-Fu F. Chen Shen-Ju Chou Specific contribution of neurons from the Dbx1 lineage to the piriform cortex
description	Abstract The piriform cortex (PC) is a major cortical processing center for the sense of smell that receives direct inputs from the olfactory bulb. In mice, the PC consists of three neuronal layers, which are populated by cells with distinct developmental origins. One origin of PC neurons is the pool of Dbx1-expressing neural progenitors located in the ventral pallium at the pallial-subpallial boundary. Since the precise mechanisms of PC neuron development are largely unknown, we sought to define the distribution, timing of neurogenesis, morphology and projection patterns of PC neurons from the Dbx1 lineage. We found that Dbx1-lineage neurons are preferentially distributed in layer 2 and enriched in the ventral portion of the PC. Further, Dbx1 neurons are early-born neurons and contribute to most neuronal subtypes in the PC. Our data also revealed an enrichment of Dbx1-lineage neurons in the ventral anterior PC that project to the orbitofrontal cortex. These findings suggest a specific association between the developmental origin of PC neurons and their neuronal properties.
format	article
author	Thando Shabangu Hung-Lun Chen Zi-hui Zhuang Alessandra Pierani Chien-Fu F. Chen Shen-Ju Chou
author_facet	Thando Shabangu Hung-Lun Chen Zi-hui Zhuang Alessandra Pierani Chien-Fu F. Chen Shen-Ju Chou
author_sort	Thando Shabangu
title	Specific contribution of neurons from the Dbx1 lineage to the piriform cortex
title_short	Specific contribution of neurons from the Dbx1 lineage to the piriform cortex
title_full	Specific contribution of neurons from the Dbx1 lineage to the piriform cortex
title_fullStr	Specific contribution of neurons from the Dbx1 lineage to the piriform cortex
title_full_unstemmed	Specific contribution of neurons from the Dbx1 lineage to the piriform cortex
title_sort	specific contribution of neurons from the dbx1 lineage to the piriform cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5356334909ca4d4388dae6b6c4e8281f
work_keys_str_mv	AT thandoshabangu specificcontributionofneuronsfromthedbx1lineagetothepiriformcortex AT hunglunchen specificcontributionofneuronsfromthedbx1lineagetothepiriformcortex AT zihuizhuang specificcontributionofneuronsfromthedbx1lineagetothepiriformcortex AT alessandrapierani specificcontributionofneuronsfromthedbx1lineagetothepiriformcortex AT chienfufchen specificcontributionofneuronsfromthedbx1lineagetothepiriformcortex AT shenjuchou specificcontributionofneuronsfromthedbx1lineagetothepiriformcortex
_version_	1718378686651039744

Specific contribution of neurons from the Dbx1 lineage to the piriform cortex

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