Quenching protein dynamics interferes with HIV capsid maturation

The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mingzhang Wang, Caitlin M. Quinn, Juan R. Perilla, Huilan Zhang, Randall Shirra Jr., Guangjin Hou, In-Ja Byeon, Christopher L. Suiter, Sherimay Ablan, Emiko Urano, Theodore J. Nitz, Christopher Aiken, Eric O. Freed, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, Tatyana Polenova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53603f9efdef492b8a17f6357f9858ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53603f9efdef492b8a17f6357f9858ed
record_format	dspace
spelling	oai:doaj.org-article:53603f9efdef492b8a17f6357f9858ed2021-12-02T17:06:20ZQuenching protein dynamics interferes with HIV capsid maturation10.1038/s41467-017-01856-y2041-1723https://doaj.org/article/53603f9efdef492b8a17f6357f9858ed2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01856-yhttps://doaj.org/toc/2041-1723The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.Mingzhang WangCaitlin M. QuinnJuan R. PerillaHuilan ZhangRandall Shirra Jr.Guangjin HouIn-Ja ByeonChristopher L. SuiterSherimay AblanEmiko UranoTheodore J. NitzChristopher AikenEric O. FreedPeijun ZhangKlaus SchultenAngela M. GronenbornTatyana PolenovaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingzhang Wang Caitlin M. Quinn Juan R. Perilla Huilan Zhang Randall Shirra Jr. Guangjin Hou In-Ja Byeon Christopher L. Suiter Sherimay Ablan Emiko Urano Theodore J. Nitz Christopher Aiken Eric O. Freed Peijun Zhang Klaus Schulten Angela M. Gronenborn Tatyana Polenova Quenching protein dynamics interferes with HIV capsid maturation
description	The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.
format	article
author	Mingzhang Wang Caitlin M. Quinn Juan R. Perilla Huilan Zhang Randall Shirra Jr. Guangjin Hou In-Ja Byeon Christopher L. Suiter Sherimay Ablan Emiko Urano Theodore J. Nitz Christopher Aiken Eric O. Freed Peijun Zhang Klaus Schulten Angela M. Gronenborn Tatyana Polenova
author_facet	Mingzhang Wang Caitlin M. Quinn Juan R. Perilla Huilan Zhang Randall Shirra Jr. Guangjin Hou In-Ja Byeon Christopher L. Suiter Sherimay Ablan Emiko Urano Theodore J. Nitz Christopher Aiken Eric O. Freed Peijun Zhang Klaus Schulten Angela M. Gronenborn Tatyana Polenova
author_sort	Mingzhang Wang
title	Quenching protein dynamics interferes with HIV capsid maturation
title_short	Quenching protein dynamics interferes with HIV capsid maturation
title_full	Quenching protein dynamics interferes with HIV capsid maturation
title_fullStr	Quenching protein dynamics interferes with HIV capsid maturation
title_full_unstemmed	Quenching protein dynamics interferes with HIV capsid maturation
title_sort	quenching protein dynamics interferes with hiv capsid maturation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53603f9efdef492b8a17f6357f9858ed
work_keys_str_mv	AT mingzhangwang quenchingproteindynamicsinterfereswithhivcapsidmaturation AT caitlinmquinn quenchingproteindynamicsinterfereswithhivcapsidmaturation AT juanrperilla quenchingproteindynamicsinterfereswithhivcapsidmaturation AT huilanzhang quenchingproteindynamicsinterfereswithhivcapsidmaturation AT randallshirrajr quenchingproteindynamicsinterfereswithhivcapsidmaturation AT guangjinhou quenchingproteindynamicsinterfereswithhivcapsidmaturation AT injabyeon quenchingproteindynamicsinterfereswithhivcapsidmaturation AT christopherlsuiter quenchingproteindynamicsinterfereswithhivcapsidmaturation AT sherimayablan quenchingproteindynamicsinterfereswithhivcapsidmaturation AT emikourano quenchingproteindynamicsinterfereswithhivcapsidmaturation AT theodorejnitz quenchingproteindynamicsinterfereswithhivcapsidmaturation AT christopheraiken quenchingproteindynamicsinterfereswithhivcapsidmaturation AT ericofreed quenchingproteindynamicsinterfereswithhivcapsidmaturation AT peijunzhang quenchingproteindynamicsinterfereswithhivcapsidmaturation AT klausschulten quenchingproteindynamicsinterfereswithhivcapsidmaturation AT angelamgronenborn quenchingproteindynamicsinterfereswithhivcapsidmaturation AT tatyanapolenova quenchingproteindynamicsinterfereswithhivcapsidmaturation
_version_	1718381612106776576

Quenching protein dynamics interferes with HIV capsid maturation

Ejemplares similares