BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Case report: Haemorrhagic cystitis (HC) is characterized by focal or diffuse haemorrhagic and inflammatory changes of the bladder mucosa. Polyoma BK virus (BKV) infection is an important underlying condition that provokes hematopoietic stem cell transplantation (HSCT)-related HC. Although commonly r...

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Autores principales:	Aslı Turgutoğlu Yılmaz, Dilek Kacar, H. Nese Yarali, Namik Yasar Ozbek
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/53617645bec449408425e27467454470
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spelling	oai:doaj.org-article:53617645bec449408425e274674544702021-11-10T04:38:23ZBK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA2531-137910.1016/j.htct.2021.10.1077https://doaj.org/article/53617645bec449408425e274674544702021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921012244https://doaj.org/toc/2531-1379Case report: Haemorrhagic cystitis (HC) is characterized by focal or diffuse haemorrhagic and inflammatory changes of the bladder mucosa. Polyoma BK virus (BKV) infection is an important underlying condition that provokes hematopoietic stem cell transplantation (HSCT)-related HC. Although commonly reported in transplant recipients, BKV associated HC, and tubulointerstitial nephritis rarely occurs in paediatric acute lymphoblastic leukemia (ALL) patients receiving chemotherapy. A 15-year-old girl diagnosed with T cell ALL, receiving high-risk chemotherapy protocol, complained about dysuria and lower abdominal pain with macroscopic haematuria. Her complaints started under meropenem, teicoplanin, amikacin, and caspofungin treatment due to neutropenic fever with severe mucositis. There wasn't any bacterial growth in the urine or blood culture. PCR analysis detected 2,2 × 109 copies/mL of BKV in urine. The antibiotics other than ciprofloxacin were discontinued. Her complaints are alleviated day by day. She did not experience any urinary symptoms or haematuria, and the BKV copy number declined to 3,3 × 107 copies/mL during follow-up.Contributing factors of BKV associated HC are highly relevant in HSCT recipients. However, patients receiving intensive chemotherapy may have similar conditions. A predisposing and potential manageable factor such as BKV should be searched in paediatric haematology practice.Aslı Turgutoğlu YılmazDilek KacarH. Nese YaraliNamik Yasar OzbekElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S58- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Aslı Turgutoğlu Yılmaz Dilek Kacar H. Nese Yarali Namik Yasar Ozbek BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA
description	Case report: Haemorrhagic cystitis (HC) is characterized by focal or diffuse haemorrhagic and inflammatory changes of the bladder mucosa. Polyoma BK virus (BKV) infection is an important underlying condition that provokes hematopoietic stem cell transplantation (HSCT)-related HC. Although commonly reported in transplant recipients, BKV associated HC, and tubulointerstitial nephritis rarely occurs in paediatric acute lymphoblastic leukemia (ALL) patients receiving chemotherapy. A 15-year-old girl diagnosed with T cell ALL, receiving high-risk chemotherapy protocol, complained about dysuria and lower abdominal pain with macroscopic haematuria. Her complaints started under meropenem, teicoplanin, amikacin, and caspofungin treatment due to neutropenic fever with severe mucositis. There wasn't any bacterial growth in the urine or blood culture. PCR analysis detected 2,2 × 109 copies/mL of BKV in urine. The antibiotics other than ciprofloxacin were discontinued. Her complaints are alleviated day by day. She did not experience any urinary symptoms or haematuria, and the BKV copy number declined to 3,3 × 107 copies/mL during follow-up.Contributing factors of BKV associated HC are highly relevant in HSCT recipients. However, patients receiving intensive chemotherapy may have similar conditions. A predisposing and potential manageable factor such as BKV should be searched in paediatric haematology practice.
format	article
author	Aslı Turgutoğlu Yılmaz Dilek Kacar H. Nese Yarali Namik Yasar Ozbek
author_facet	Aslı Turgutoğlu Yılmaz Dilek Kacar H. Nese Yarali Namik Yasar Ozbek
author_sort	Aslı Turgutoğlu Yılmaz
title	BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_short	BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_full	BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_fullStr	BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_full_unstemmed	BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_sort	bk-virus associated haemorrhagic cystitis concomitant with chemotherapy in an adolescent girl with acute lymphoblastic leukemia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/53617645bec449408425e27467454470
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BK-VIRUS ASSOCIATED HAEMORRHAGIC CYSTITIS CONCOMITANT WITH CHEMOTHERAPY IN AN ADOLESCENT GIRL WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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