CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain boundaries, suggesting differences in the role o...

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Autores principales:	Anjali Kaushal, Giriram Mohana, Julien Dorier, Isa Özdemir, Arina Omer, Pascal Cousin, Anastasiia Semenova, Michael Taschner, Oleksandr Dergai, Flavia Marzetta, Christian Iseli, Yossi Eliaz, David Weisz, Muhammad Saad Shamim, Nicolas Guex, Erez Lieberman Aiden, Maria Cristina Gambetta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53617b4d9398422ba368c6a80e44f9a5
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spelling	oai:doaj.org-article:53617b4d9398422ba368c6a80e44f9a52021-12-02T13:30:14ZCTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions10.1038/s41467-021-21366-22041-1723https://doaj.org/article/53617b4d9398422ba368c6a80e44f9a52021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21366-2https://doaj.org/toc/2041-1723Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain boundaries, suggesting differences in the role of CTCF for genome folding in flies and vertebrates.Anjali KaushalGiriram MohanaJulien DorierIsa ÖzdemirArina OmerPascal CousinAnastasiia SemenovaMichael TaschnerOleksandr DergaiFlavia MarzettaChristian IseliYossi EliazDavid WeiszMuhammad Saad ShamimNicolas GuexErez Lieberman AidenMaria Cristina GambettaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anjali Kaushal Giriram Mohana Julien Dorier Isa Özdemir Arina Omer Pascal Cousin Anastasiia Semenova Michael Taschner Oleksandr Dergai Flavia Marzetta Christian Iseli Yossi Eliaz David Weisz Muhammad Saad Shamim Nicolas Guex Erez Lieberman Aiden Maria Cristina Gambetta CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
description	Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain boundaries, suggesting differences in the role of CTCF for genome folding in flies and vertebrates.
format	article
author	Anjali Kaushal Giriram Mohana Julien Dorier Isa Özdemir Arina Omer Pascal Cousin Anastasiia Semenova Michael Taschner Oleksandr Dergai Flavia Marzetta Christian Iseli Yossi Eliaz David Weisz Muhammad Saad Shamim Nicolas Guex Erez Lieberman Aiden Maria Cristina Gambetta
author_facet	Anjali Kaushal Giriram Mohana Julien Dorier Isa Özdemir Arina Omer Pascal Cousin Anastasiia Semenova Michael Taschner Oleksandr Dergai Flavia Marzetta Christian Iseli Yossi Eliaz David Weisz Muhammad Saad Shamim Nicolas Guex Erez Lieberman Aiden Maria Cristina Gambetta
author_sort	Anjali Kaushal
title	CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
title_short	CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
title_full	CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
title_fullStr	CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
title_full_unstemmed	CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
title_sort	ctcf loss has limited effects on global genome architecture in drosophila despite critical regulatory functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53617b4d9398422ba368c6a80e44f9a5
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CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

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