CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain boundaries, suggesting differences in the role o...

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Auteurs principaux: Anjali Kaushal, Giriram Mohana, Julien Dorier, Isa Özdemir, Arina Omer, Pascal Cousin, Anastasiia Semenova, Michael Taschner, Oleksandr Dergai, Flavia Marzetta, Christian Iseli, Yossi Eliaz, David Weisz, Muhammad Saad Shamim, Nicolas Guex, Erez Lieberman Aiden, Maria Cristina Gambetta
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/53617b4d9398422ba368c6a80e44f9a5
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Internet

https://doaj.org/article/53617b4d9398422ba368c6a80e44f9a5

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