Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour response to immunotherapy.

Guardado en:

Detalles Bibliográficos
Autores principales:	Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu, Maise Al-Bakir, Yien Ning Sophia Wong, Andrew Rowan, Samuel A. Funt, Taha Merghoub, David Perkins, Martin Lauss, Inge Marie Svane, Göran Jönsson, Javier Herrero, James Larkin, Sergio A. Quezada, Matthew D. Hellmann, Samra Turajlic, Charles Swanton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5361db97aec7487d9e4b4732b41ccecf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5361db97aec7487d9e4b4732b41ccecf
record_format	dspace
spelling	oai:doaj.org-article:5361db97aec7487d9e4b4732b41ccecf2021-12-02T16:14:05ZEscape from nonsense-mediated decay associates with anti-tumor immunogenicity10.1038/s41467-020-17526-52041-1723https://doaj.org/article/5361db97aec7487d9e4b4732b41ccecf2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17526-5https://doaj.org/toc/2041-1723The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour response to immunotherapy.Kevin LitchfieldJames L. ReadingEmilia L. LimHang XuPo LiuMaise Al-BakirYien Ning Sophia WongAndrew RowanSamuel A. FuntTaha MerghoubDavid PerkinsMartin LaussInge Marie SvaneGöran JönssonJavier HerreroJames LarkinSergio A. QuezadaMatthew D. HellmannSamra TurajlicCharles SwantonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Litchfield James L. Reading Emilia L. Lim Hang Xu Po Liu Maise Al-Bakir Yien Ning Sophia Wong Andrew Rowan Samuel A. Funt Taha Merghoub David Perkins Martin Lauss Inge Marie Svane Göran Jönsson Javier Herrero James Larkin Sergio A. Quezada Matthew D. Hellmann Samra Turajlic Charles Swanton Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
description	The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour response to immunotherapy.
format	article
author	Kevin Litchfield James L. Reading Emilia L. Lim Hang Xu Po Liu Maise Al-Bakir Yien Ning Sophia Wong Andrew Rowan Samuel A. Funt Taha Merghoub David Perkins Martin Lauss Inge Marie Svane Göran Jönsson Javier Herrero James Larkin Sergio A. Quezada Matthew D. Hellmann Samra Turajlic Charles Swanton
author_facet	Kevin Litchfield James L. Reading Emilia L. Lim Hang Xu Po Liu Maise Al-Bakir Yien Ning Sophia Wong Andrew Rowan Samuel A. Funt Taha Merghoub David Perkins Martin Lauss Inge Marie Svane Göran Jönsson Javier Herrero James Larkin Sergio A. Quezada Matthew D. Hellmann Samra Turajlic Charles Swanton
author_sort	Kevin Litchfield
title	Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
title_short	Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
title_full	Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
title_fullStr	Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
title_full_unstemmed	Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
title_sort	escape from nonsense-mediated decay associates with anti-tumor immunogenicity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5361db97aec7487d9e4b4732b41ccecf
work_keys_str_mv	AT kevinlitchfield escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT jameslreading escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT emiliallim escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT hangxu escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT poliu escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT maisealbakir escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT yienningsophiawong escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT andrewrowan escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT samuelafunt escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT tahamerghoub escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT davidperkins escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT martinlauss escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT ingemariesvane escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT goranjonsson escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT javierherrero escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT jameslarkin escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT sergioaquezada escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT matthewdhellmann escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT samraturajlic escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity AT charlesswanton escapefromnonsensemediateddecayassociateswithantitumorimmunogenicity
_version_	1718384349844340736

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Ejemplares similares