IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if del...

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Autores principales: Sara Bisi, Stefano Marchesi, Abrar Rizvi, Davide Carra, Galina V. Beznoussenko, Ines Ferrara, Gianluca Deflorian, Alexander Mironov, Giovanni Bertalot, Federica Pisati, Amanda Oldani, Angela Cattaneo, Ghazaleh Saberamoli, Salvatore Pece, Giuseppe Viale, Angela Bachi, Claudio Tripodo, Giorgio Scita, Andrea Disanza
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/536a71339aa54d258f9d3f43f9fc0c19
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Sumario:The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.

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