IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if del...

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Autores principales:	Sara Bisi, Stefano Marchesi, Abrar Rizvi, Davide Carra, Galina V. Beznoussenko, Ines Ferrara, Gianluca Deflorian, Alexander Mironov, Giovanni Bertalot, Federica Pisati, Amanda Oldani, Angela Cattaneo, Ghazaleh Saberamoli, Salvatore Pece, Giuseppe Viale, Angela Bachi, Claudio Tripodo, Giorgio Scita, Andrea Disanza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/536a71339aa54d258f9d3f43f9fc0c19
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spelling	oai:doaj.org-article:536a71339aa54d258f9d3f43f9fc0c192021-12-02T17:01:30ZIRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules10.1038/s41467-020-17091-x2041-1723https://doaj.org/article/536a71339aa54d258f9d3f43f9fc0c192020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17091-xhttps://doaj.org/toc/2041-1723The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.Sara BisiStefano MarchesiAbrar RizviDavide CarraGalina V. BeznoussenkoInes FerraraGianluca DeflorianAlexander MironovGiovanni BertalotFederica PisatiAmanda OldaniAngela CattaneoGhazaleh SaberamoliSalvatore PeceGiuseppe VialeAngela BachiClaudio TripodoGiorgio ScitaAndrea DisanzaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Bisi Stefano Marchesi Abrar Rizvi Davide Carra Galina V. Beznoussenko Ines Ferrara Gianluca Deflorian Alexander Mironov Giovanni Bertalot Federica Pisati Amanda Oldani Angela Cattaneo Ghazaleh Saberamoli Salvatore Pece Giuseppe Viale Angela Bachi Claudio Tripodo Giorgio Scita Andrea Disanza IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
description	The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.
format	article
author	Sara Bisi Stefano Marchesi Abrar Rizvi Davide Carra Galina V. Beznoussenko Ines Ferrara Gianluca Deflorian Alexander Mironov Giovanni Bertalot Federica Pisati Amanda Oldani Angela Cattaneo Ghazaleh Saberamoli Salvatore Pece Giuseppe Viale Angela Bachi Claudio Tripodo Giorgio Scita Andrea Disanza
author_facet	Sara Bisi Stefano Marchesi Abrar Rizvi Davide Carra Galina V. Beznoussenko Ines Ferrara Gianluca Deflorian Alexander Mironov Giovanni Bertalot Federica Pisati Amanda Oldani Angela Cattaneo Ghazaleh Saberamoli Salvatore Pece Giuseppe Viale Angela Bachi Claudio Tripodo Giorgio Scita Andrea Disanza
author_sort	Sara Bisi
title	IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
title_short	IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
title_full	IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
title_fullStr	IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
title_full_unstemmed	IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
title_sort	irsp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/536a71339aa54d258f9d3f43f9fc0c19
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IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

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