Bypassing pan-enterovirus host factor PLA2G16

The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes pro...

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Autores principales:	Jim Baggen, Yue Liu, Heyrhyoung Lyoo, Arno L. W. van Vliet, Maryam Wahedi, Jost W. de Bruin, Richard W. Roberts, Pieter Overduin, Adam Meijer, Michael G. Rossmann, Hendrik Jan Thibaut, Frank J. M. van Kuppeveld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/536b2ca009324bba909b77f9954177af
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spelling	oai:doaj.org-article:536b2ca009324bba909b77f9954177af2021-12-02T15:35:39ZBypassing pan-enterovirus host factor PLA2G1610.1038/s41467-019-11256-z2041-1723https://doaj.org/article/536b2ca009324bba909b77f9954177af2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11256-zhttps://doaj.org/toc/2041-1723The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes promoting viral genome release.Jim BaggenYue LiuHeyrhyoung LyooArno L. W. van VlietMaryam WahediJost W. de BruinRichard W. RobertsPieter OverduinAdam MeijerMichael G. RossmannHendrik Jan ThibautFrank J. M. van KuppeveldNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jim Baggen Yue Liu Heyrhyoung Lyoo Arno L. W. van Vliet Maryam Wahedi Jost W. de Bruin Richard W. Roberts Pieter Overduin Adam Meijer Michael G. Rossmann Hendrik Jan Thibaut Frank J. M. van Kuppeveld Bypassing pan-enterovirus host factor PLA2G16
description	The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes promoting viral genome release.
format	article
author	Jim Baggen Yue Liu Heyrhyoung Lyoo Arno L. W. van Vliet Maryam Wahedi Jost W. de Bruin Richard W. Roberts Pieter Overduin Adam Meijer Michael G. Rossmann Hendrik Jan Thibaut Frank J. M. van Kuppeveld
author_facet	Jim Baggen Yue Liu Heyrhyoung Lyoo Arno L. W. van Vliet Maryam Wahedi Jost W. de Bruin Richard W. Roberts Pieter Overduin Adam Meijer Michael G. Rossmann Hendrik Jan Thibaut Frank J. M. van Kuppeveld
author_sort	Jim Baggen
title	Bypassing pan-enterovirus host factor PLA2G16
title_short	Bypassing pan-enterovirus host factor PLA2G16
title_full	Bypassing pan-enterovirus host factor PLA2G16
title_fullStr	Bypassing pan-enterovirus host factor PLA2G16
title_full_unstemmed	Bypassing pan-enterovirus host factor PLA2G16
title_sort	bypassing pan-enterovirus host factor pla2g16
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/536b2ca009324bba909b77f9954177af
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Bypassing pan-enterovirus host factor PLA2G16

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