TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM targets by MYCN/FOXM1.

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Autores principales:	Bieke Decaesteker, Geertrui Denecker, Christophe Van Neste, Emmy M. Dolman, Wouter Van Loocke, Moritz Gartlgruber, Carolina Nunes, Fanny De Vloed, Pauline Depuydt, Karen Verboom, Dries Rombaut, Siebe Loontiens, Jolien De Wyn, Waleed M. Kholosy, Bianca Koopmans, Anke H. W. Essing, Carl Herrmann, Daniel Dreidax, Kaat Durinck, Dieter Deforce, Filip Van Nieuwerburgh, Anton Henssen, Rogier Versteeg, Valentina Boeva, Gudrun Schleiermacher, Johan van Nes, Pieter Mestdagh, Suzanne Vanhauwaert, Johannes H. Schulte, Frank Westermann, Jan J. Molenaar, Katleen De Preter, Frank Speleman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/536b907629694780b1f507b113373066
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spelling	oai:doaj.org-article:536b907629694780b1f507b1133730662021-12-02T15:34:37ZTBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets10.1038/s41467-018-06699-92041-1723https://doaj.org/article/536b907629694780b1f507b1133730662018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06699-9https://doaj.org/toc/2041-1723In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM targets by MYCN/FOXM1.Bieke DecaestekerGeertrui DeneckerChristophe Van NesteEmmy M. DolmanWouter Van LoockeMoritz GartlgruberCarolina NunesFanny De VloedPauline DepuydtKaren VerboomDries RombautSiebe LoontiensJolien De WynWaleed M. KholosyBianca KoopmansAnke H. W. EssingCarl HerrmannDaniel DreidaxKaat DurinckDieter DeforceFilip Van NieuwerburghAnton HenssenRogier VersteegValentina BoevaGudrun SchleiermacherJohan van NesPieter MestdaghSuzanne VanhauwaertJohannes H. SchulteFrank WestermannJan J. MolenaarKatleen De PreterFrank SpelemanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bieke Decaesteker Geertrui Denecker Christophe Van Neste Emmy M. Dolman Wouter Van Loocke Moritz Gartlgruber Carolina Nunes Fanny De Vloed Pauline Depuydt Karen Verboom Dries Rombaut Siebe Loontiens Jolien De Wyn Waleed M. Kholosy Bianca Koopmans Anke H. W. Essing Carl Herrmann Daniel Dreidax Kaat Durinck Dieter Deforce Filip Van Nieuwerburgh Anton Henssen Rogier Versteeg Valentina Boeva Gudrun Schleiermacher Johan van Nes Pieter Mestdagh Suzanne Vanhauwaert Johannes H. Schulte Frank Westermann Jan J. Molenaar Katleen De Preter Frank Speleman TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
description	In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM targets by MYCN/FOXM1.
format	article
author	Bieke Decaesteker Geertrui Denecker Christophe Van Neste Emmy M. Dolman Wouter Van Loocke Moritz Gartlgruber Carolina Nunes Fanny De Vloed Pauline Depuydt Karen Verboom Dries Rombaut Siebe Loontiens Jolien De Wyn Waleed M. Kholosy Bianca Koopmans Anke H. W. Essing Carl Herrmann Daniel Dreidax Kaat Durinck Dieter Deforce Filip Van Nieuwerburgh Anton Henssen Rogier Versteeg Valentina Boeva Gudrun Schleiermacher Johan van Nes Pieter Mestdagh Suzanne Vanhauwaert Johannes H. Schulte Frank Westermann Jan J. Molenaar Katleen De Preter Frank Speleman
author_facet	Bieke Decaesteker Geertrui Denecker Christophe Van Neste Emmy M. Dolman Wouter Van Loocke Moritz Gartlgruber Carolina Nunes Fanny De Vloed Pauline Depuydt Karen Verboom Dries Rombaut Siebe Loontiens Jolien De Wyn Waleed M. Kholosy Bianca Koopmans Anke H. W. Essing Carl Herrmann Daniel Dreidax Kaat Durinck Dieter Deforce Filip Van Nieuwerburgh Anton Henssen Rogier Versteeg Valentina Boeva Gudrun Schleiermacher Johan van Nes Pieter Mestdagh Suzanne Vanhauwaert Johannes H. Schulte Frank Westermann Jan J. Molenaar Katleen De Preter Frank Speleman
author_sort	Bieke Decaesteker
title	TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
title_short	TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
title_full	TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
title_fullStr	TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
title_full_unstemmed	TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
title_sort	tbx2 is a neuroblastoma core regulatory circuitry component enhancing mycn/foxm1 reactivation of dream targets
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/536b907629694780b1f507b113373066
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TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

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