New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

Currently, adipose tissue is considered an endocrine organ, however, there are still many questions regarding the roles of adipokines—leptin and ghrelin being two adipokines. The purpose of the study was to assess the relationship between the adipokines and their ratio with obesity and diabetes. Met...

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Autores principales:	Adela-Viviana Sitar-Tǎut, Angela Cozma, Adriana Fodor, Sorina-Cezara Coste, Olga Hilda Orasan, Vasile Negrean, Dana Pop, Dan-Andrei Sitar-Tǎut
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity body mass index diabetes leptin ghrelin Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/536c045c7e284b63be117eff588fce89
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spelling	oai:doaj.org-article:536c045c7e284b63be117eff588fce892021-11-25T16:50:21ZNew Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes10.3390/biomedicines91116572227-9059https://doaj.org/article/536c045c7e284b63be117eff588fce892021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1657https://doaj.org/toc/2227-9059Currently, adipose tissue is considered an endocrine organ, however, there are still many questions regarding the roles of adipokines—leptin and ghrelin being two adipokines. The purpose of the study was to assess the relationship between the adipokines and their ratio with obesity and diabetes. Methods: Sixty patients (mean age 61.88 ± 10.08) were evaluated. Cardiovascular risk factors, leptin, ghrelin, and insulin resistance score values were assessed. The patients were classified according to their body mass index (BMI) as normal weight, overweight, and obese. Results: 20% normal weight, 51.7% overweight, 28.3% obese, and 23.3% diabetic. Obese patients had higher leptin values (in obese 34,360 pg/mL vs. overweight 18,000 pg/mL vs. normal weight 14,350 pg/mL, <i>p</i> = 0.0049) and leptin/ghrelin ratio (1055 ± 641 vs. 771.36 ± 921 vs. 370.7 ± 257, <i>p</i> = 0.0228). Stratifying the analyses according to the presence of obesity and patients’ gender, differences were found for leptin (<i>p</i> = 0.0020 in women, <i>p</i> = 0.0055 in men) and leptin/ghrelin ratio (<i>p</i> = 0.048 in women, <i>p</i> = 0.004 in men). Mean leptin/BMI and leptin/ghrelin/BMI ratios were significantly higher, and the ghrelin/BMI ratio was significantly lower in obese and diabetic patients. In conclusion, obesity and diabetes are associated with changes not only in the total amount but also in the level of adipokines/kg/m<sup>2</sup>. Changes appear even in overweight subjects, offering a basis for early intervention in diabetic and obese patients.Adela-Viviana Sitar-TǎutAngela CozmaAdriana FodorSorina-Cezara CosteOlga Hilda OrasanVasile NegreanDana PopDan-Andrei Sitar-TǎutMDPI AGarticleobesitybody mass indexdiabetesleptinghrelinBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1657, p 1657 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity body mass index diabetes leptin ghrelin Biology (General) QH301-705.5
spellingShingle	obesity body mass index diabetes leptin ghrelin Biology (General) QH301-705.5 Adela-Viviana Sitar-Tǎut Angela Cozma Adriana Fodor Sorina-Cezara Coste Olga Hilda Orasan Vasile Negrean Dana Pop Dan-Andrei Sitar-Tǎut New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes
description	Currently, adipose tissue is considered an endocrine organ, however, there are still many questions regarding the roles of adipokines—leptin and ghrelin being two adipokines. The purpose of the study was to assess the relationship between the adipokines and their ratio with obesity and diabetes. Methods: Sixty patients (mean age 61.88 ± 10.08) were evaluated. Cardiovascular risk factors, leptin, ghrelin, and insulin resistance score values were assessed. The patients were classified according to their body mass index (BMI) as normal weight, overweight, and obese. Results: 20% normal weight, 51.7% overweight, 28.3% obese, and 23.3% diabetic. Obese patients had higher leptin values (in obese 34,360 pg/mL vs. overweight 18,000 pg/mL vs. normal weight 14,350 pg/mL, <i>p</i> = 0.0049) and leptin/ghrelin ratio (1055 ± 641 vs. 771.36 ± 921 vs. 370.7 ± 257, <i>p</i> = 0.0228). Stratifying the analyses according to the presence of obesity and patients’ gender, differences were found for leptin (<i>p</i> = 0.0020 in women, <i>p</i> = 0.0055 in men) and leptin/ghrelin ratio (<i>p</i> = 0.048 in women, <i>p</i> = 0.004 in men). Mean leptin/BMI and leptin/ghrelin/BMI ratios were significantly higher, and the ghrelin/BMI ratio was significantly lower in obese and diabetic patients. In conclusion, obesity and diabetes are associated with changes not only in the total amount but also in the level of adipokines/kg/m<sup>2</sup>. Changes appear even in overweight subjects, offering a basis for early intervention in diabetic and obese patients.
format	article
author	Adela-Viviana Sitar-Tǎut Angela Cozma Adriana Fodor Sorina-Cezara Coste Olga Hilda Orasan Vasile Negrean Dana Pop Dan-Andrei Sitar-Tǎut
author_facet	Adela-Viviana Sitar-Tǎut Angela Cozma Adriana Fodor Sorina-Cezara Coste Olga Hilda Orasan Vasile Negrean Dana Pop Dan-Andrei Sitar-Tǎut
author_sort	Adela-Viviana Sitar-Tǎut
title	New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes
title_short	New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes
title_full	New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes
title_fullStr	New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes
title_full_unstemmed	New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes
title_sort	new insights on the relationship between leptin, ghrelin, and leptin/ghrelin ratio enforced by body mass index in obesity and diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/536c045c7e284b63be117eff588fce89
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New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

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