L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals

As a functional monosaccharide, L-arabinose has protective effects on metabolic syndrome, but whether it is effective for cerebral ischemia in diabetic patients remains unknown. The middle cerebral artery occlusion (MCAO) model of type 2 diabetic rats was prepared and applied to determine the effect...

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Autores principales:	Haiyan Li, Rui Ding, Yilong Shan, Fei Ye, Yinyao Lin, Xuejiao Men, Chengwei Chen, Sha Tan, Qiujing Wang, Biao Hu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	L-arabinose Cerebral infarction Diabetes mellitus Neurovascular protection Blood-brain barrier Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/536d22e0066944119125940092e42ab4
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spelling	oai:doaj.org-article:536d22e0066944119125940092e42ab42021-11-10T04:21:55ZL-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals1756-464610.1016/j.jff.2021.104839https://doaj.org/article/536d22e0066944119125940092e42ab42021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004886https://doaj.org/toc/1756-4646As a functional monosaccharide, L-arabinose has protective effects on metabolic syndrome, but whether it is effective for cerebral ischemia in diabetic patients remains unknown. The middle cerebral artery occlusion (MCAO) model of type 2 diabetic rats was prepared and applied to determine the effect of L-arabinose on cerebral infarction (CI) with or without diabetes. Results showed that diabetes aggravated neurological deficits, increased the volume of CI, brain edema, and blood–brain barrier (BBB) permeability after CI, which were alleviated by L-arabinose by repairing the damaged tight-junction proteins (zonula occludens 1 and claudin-5). L-arabinose could reverse the expression of nuclear factor-κB (NF-κB) p65, intercellular cell adhesion molecule-1, and tumor necrosis factor α in the MCAO model with diabetes. Conclusions: L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by alleviating the destruction of the BBB via the downregulation of the NF-κB signaling pathway.Haiyan LiRui DingYilong ShanFei YeYinyao LinXuejiao MenChengwei ChenSha TanQiujing WangBiao HuElsevierarticleL-arabinoseCerebral infarctionDiabetes mellitusNeurovascular protectionBlood-brain barrierNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104839- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	L-arabinose Cerebral infarction Diabetes mellitus Neurovascular protection Blood-brain barrier Nutrition. Foods and food supply TX341-641
spellingShingle	L-arabinose Cerebral infarction Diabetes mellitus Neurovascular protection Blood-brain barrier Nutrition. Foods and food supply TX341-641 Haiyan Li Rui Ding Yilong Shan Fei Ye Yinyao Lin Xuejiao Men Chengwei Chen Sha Tan Qiujing Wang Biao Hu L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals
description	As a functional monosaccharide, L-arabinose has protective effects on metabolic syndrome, but whether it is effective for cerebral ischemia in diabetic patients remains unknown. The middle cerebral artery occlusion (MCAO) model of type 2 diabetic rats was prepared and applied to determine the effect of L-arabinose on cerebral infarction (CI) with or without diabetes. Results showed that diabetes aggravated neurological deficits, increased the volume of CI, brain edema, and blood–brain barrier (BBB) permeability after CI, which were alleviated by L-arabinose by repairing the damaged tight-junction proteins (zonula occludens 1 and claudin-5). L-arabinose could reverse the expression of nuclear factor-κB (NF-κB) p65, intercellular cell adhesion molecule-1, and tumor necrosis factor α in the MCAO model with diabetes. Conclusions: L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by alleviating the destruction of the BBB via the downregulation of the NF-κB signaling pathway.
format	article
author	Haiyan Li Rui Ding Yilong Shan Fei Ye Yinyao Lin Xuejiao Men Chengwei Chen Sha Tan Qiujing Wang Biao Hu
author_facet	Haiyan Li Rui Ding Yilong Shan Fei Ye Yinyao Lin Xuejiao Men Chengwei Chen Sha Tan Qiujing Wang Biao Hu
author_sort	Haiyan Li
title	L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals
title_short	L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals
title_full	L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals
title_fullStr	L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals
title_full_unstemmed	L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals
title_sort	l-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating nf-κb signals
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/536d22e0066944119125940092e42ab4
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L-arabinose alleviates diabetes-aggravated cerebral ischemic injury by repairing the blood-brain barrier via downregulating NF-κB signals

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